ABSTRACT
Objective: To determine the frequency and etiological factors of nonneoplastic and neoplastic liver diseases
Study Design: Observational / analytic study
Place and Duration of Study: This study was conducted at the Department of Pathology, BMSI, JPMC from 1st January 2012 to 31st September 2014
Materials and Methods: A total of 288 liver biopsycases of formalin fixed liver tissue biopsies were selected and analyzed for morphological features and grading received from January 2010-December 2012, at the department of Pathology, Basic Medical Sciences Institute, Jinnah Post Graduate Medical Centre. Most common liver disease was CLD [88.54%]. Most common age for CLD was between 3rd-5th decades of life with male predominance. HCV was the most common etiological factor. Out of total cases, 6.59% were hepatocellular and bile duct carcinomas. Most common age for liver cancers was 5th-7th decade of life with male predominance. The data feeding and analysis were on computer package SPSS [Statistical Packages of Social Sciences] version 20.0. In all statistical analysis only p-value <0.05 was considered significant
Results: The most commonly encountered liver disease CLD was found as a major liver disease [71%] of the samples were suffering from CLD, while 25 % were suffering from HCC, Hepatitis C was the major cause of the liver diseases, [55.56%] of the liver patients were earlier suffering from the Hepatitis C
Conclusion: In conclusion we observed that the most common liver disease in biopsy cases is chronic liver disease [chronic hepatitis], mostly occur between 21-50 years of age with male predominance and most frequent etiological factor is HCV