ABSTRACT
Objective: To investigate the role of glutathione peroxidase 1 [GPX1] C/T polymorphism [rs1800668] in modulating the chances of Rheumatoid arthritis [RA] in Pakistani population
Methods:A total of 400 individuals including 200 controls and 200 patients of RA, were genotyped. Detection of rs1800668 polymorphism was carried out using PCR based amplification strategy [allele specific]
Results:The results for Hardy Weinberg Equilibrium [HWE] indicated that the allele frequencies for GPX1 polymorphism were not deviant from HWE in whole population under observation. The statistical analysis indicated that significant association existed between rs1800668 polymorphism and RA [p<0.01]. CT genotype increased the risk of RA development by 1.8582 times [OR: 1.8582; 95% CI 1.2154 to 2.8409]. CC genotype was found to have protective effect against the disease development [OR: 0.5133; 95% CI 0.3403 to 0.7742] while TT genotype was found to have association with RA development but the risk level was marginal [OR: 1.5319; 95% CI 0.6124 to 3.8322]
Conclusion:The present finding suggests the importance of GPX1 C/T polymorphism [rs1800668] in development of RA in Pakistani population. The protective role of CC genotype against the development of RA in local population was also observed
ABSTRACT
The study was designed to determine the frequency, awareness, treatment and control of high blood pressure among the bank employees of Bahawalpur City. It was an observational, cross-sectional study, carried out by the Department of Cardiology, BVH, Bahawalpur. The study was done from 1[st] December 2006 to 22[nd] September 2007. A sample of 188 bank employees working in different banks was taken by convenience sampling technique. Bankers of all ages and both sexes were included and those absent at the time of visits and temporary trainees were excluded. The subjects were interviewed and examined according to Equipment, Condition of patient and Techniques [ECT] recommendations as laid down by US JNC 7[th] report. The data was collected on a questionnaire and was analyzed manually. Frequency of hypertension in bank employees was 40.96%. Almost half [51.94] of the hypertensives were aware of their disease and the other half were screened during this study. Out of 40 diagnosed patients of HTN, only 23 [57.5%] were taking anti-hypertensive therapy and among those, only 14 [60.87%] were having adequate control of their blood pressure. Hypertension was found to be more frequent among males as compared to females. Other associated risk factors were advancing age, BMI >27, family history of hypertension, tobacco smoking and lack of physical exercise. The study shows a high frequency, low awareness, bad treatment compliance and improvable control of hypertension among the bank employees of Bahawalpur City