Total antioxidant status in women with breast cancer

To measure the concentration of total antioxidant status [TAS] in women with breast cancer. This is a case control study conducted in Al-Salam Hospital and Department of Pharmacology in Mosul Medical College. Twenty women having histologically confirmed breast cancer and twenty age-matched healthy volunteer women participated in the study. Serum total antioxidant status [TAS] was measured in both groups. Mean TAS of the patient group [0.91 +/- 0.32 mmol/l] was significantly lower [P<0.001] than that of the control group [1.82 +/- 0.14 mmol/l]. The present study demonstrated that women with breast cancer have a low level of TAS as compared to those of healthy women. It further emphasizes the growing concern that oxidative damage may occur in those patients that exhaust the antioxidant defense of the body leading to a low levels of TAS. Administration of antioxidant supplements such as a combination of vitamins A, C and E are necessary in women at high risk of developing breast cancer or after surgery or with anticancer drugs

Antioxidant status in type 2 diabetic neuropathy

To measure the concentration of total antioxidant status [TAS] in type 2 diabetes mellitus patients complicated with peripheral neuropathy. Case-control study. The College of Medicine and Al-Wafaa Center of Diabetes, Mosul. Thirty type 2 diabetic patients, having evidence of distal symmetrical polyneuropathy and thirty sex and age-matched healthy volunteers participated in the study. Serum glucose concentration and total antioxidant status [TAS] was measured in both groups. Mean fasting blood sugar of the patient group [11.31 +/- 2.84 mmol/L] was significantly higher [p<0.001] than that of the control group [4.97 +/- 0.95 mmol/L]. Mean TAS of the patient group [1.31 +/- 0.42 mmol/L] was significantly lower [p<0.001] than that of the control group [1.98 +/- 0.16 mmol/L]. The present study demonstrated that type 2 diabetic patients with peripheral neuropathic complications have lower levels of TAS. This low value of TAS may be due to oxidative stress caused by hyperglycemia that reduce the concentration of the antioxidant status of the body

total antioxidant status in cigarette smoking individuals

Active smokers are exposed to reactive free radicals that are present in cigarette smoke. Oxygen free radicals, including superoxide, hydroxyl radicals, peroxyl radical hydrogen peroxide and singlet oxygen, are highly reactive species that can cause a wide spectrum of cell damage including enzyme inactivation, lipid peroxidation, protein and lipoprotein oxidation, and DNA damage. Free radicals are believed to be involved in the pathogenesis of cardiovascular diseases and cancer. The purpose of the present study was to measure the total antioxidant status [TAS] in active cigarette smoking individuals in Mosul city. Twenty active smokers and twenty nonsmokers participated in the study. Blood sample was taken from each individual and the TAS had been measured in the sera using the Cayman chemical antioxidant assay kit [USA]. The results obtained from the study revealed a significant [P<0.001] reduction of the TAS in the smoker's group as compared with the non-smoker's group. In conclusion, smokers possess low TAS than non smokers which may be due to the presence of high amounts of free radicals in cigarette smoke that generate an oxidative stress in the smoker's body that may cause exhaustion of antioxidants of the body