ABSTRACT
The emerging field of metabolomics had profound importance in recent years as its wide applications in the field of drug discovery and drug development. With recent advances in the field of metabolomics it can be proved as a major tool in the process of drug discovery and development. In the agricultural/chemical industry, metabolomics may be used to develop herbicides and pesticides With increasing importance being placed on health and safety related aspects of our food, metabolomics can potentially be a valuable tool to monitor and improve the quality of what we eat; for example, in food processing and quality control, or in plant breeding for improved crop varieties and in the development of novel foodstuffs. The present review reveals the importance of metabolomics in drug discovery along with recent advances in the techniques of metabolomics along with its wide applications in various fields like drug discovery, drug toxicity profiling, food industries especially in food and allied beverages testing.
ABSTRACT
Microspheres are multi-component system provide constant and prolonged drug release. Furthermore their floating abilities increase gastric residence time. These properties reduce the gastrointestinal toxic effects and dosing frequency and thereby improve the patient compliance. The present study aimed to formulate and evaluate telmisartan microspheres. Emulsion solvent evaporation (ESE) technique was employed for microsphere preparation using different ratios of ethyl cellulose polymer and drug. Prepared microspheres were evaluated for drug entrapment efficiency, micromeritic characters, floating behaviour and in vitro drug release. This revealed polymer drug ratio has influence on drug release.