ABSTRACT
Introduction: Schizophrenia is a debilitating disorder, whichhas affected the lives of the diseased & the people aroundthem in troublesome. New interventions are made regularly forthe best outcomes from the available treatments. Aim of thestudy of to compare the efficacy & side-effect profile of the newdrug-Lurasidone with other atypical anti-psychoticsolanzapine, risperidone & quitiapine.Materials & Methods: The presented study was conductedover the duration of 15 months (January 2018- March 2019).This study comprises of 100 subjects, who were divided in 4groups & drugs were randomly provided to them (25 each).Subjects were evaluated using various instruments.Results: It was found that the efficacy of Lurasidone wasalmost similar to other drugs, although scoring better withPANSS & BPRS. Metabolic changes i.e., serum cholesterol,serum LDL, HDL, VLDL levels were found greater in otherdrugs as compared to lurasidone. Fasting glucose levels andweight gain were found to be increased in drugs especiallyolanzapine when compared with lurasidone.