ABSTRACT
Background: Obesity has become a common problem worldwide due to changes in lifestyle and food habits. Obesity has been associated with many chronic diseases like diabetes mellitus, hypertension, gallstones etc. Excessive adipose tissue through release of adipokines maybe a risk factor for derangements in iron parameters. Authors aim is to study Serum Iron, TIBC, and Serum Ferritin levels in Obese women (BMI >25 kg/m2) in age group of 16 to 45 years and its comparison with normal BMI women.Methods: The case control study was conducted on 100 patients divided into two groups. Group A included 50 patients of obese women (BMI >25 kg/m2) in age group of 16 to 45 years. Group B consists of 50 control patients in similar age group with BMI of 18-23 kg/m2. Serum Iron, TIBC, and Serum Ferritin levels were measured in both groups and compared.Results: The study showed significant derangements of iron parameters in obese women.Serum Ferritin was significantly raised (p<0.001) in obese women whereas Serum Iron and TIBC were significantly decreased in obese women as compared to control group. No significant difference was seen in Serum Hemoglobin and MCV.Conclusions: Obesity is associated with derangements in iron parameters in women of reproductive age group similar to derangements seen in chronic inflammatory state.
ABSTRACT
Background: Following Myocardial Infarction some proteins and enzymes, CPK-MB/ Troponin-I, T, are released into the blood from the necrotic heart muscle. Serum Uric Acid (SUA) may be a risk factor and negative prognostic marker for cardiovascular diseases. Aim of the study was to study serum uric acid levels in patients of acute Myocardial infarction with congestive heart failure, its relation with stages of congestive heart failure as per Killip classification and the role of serum uric acid levels as a marker of mortality.Methods: The case control study was conducted on 120 patients divided into two groups. Group A included 60 patients of acute Myocardial infarction. Group A was further divided into two categories. One includes 30 patients of with congestive heart failure and another includes 30 patients without congestive heart failure. Group B consists of 60 control patients. Serum uric acid levels were measured in Group A on 1st, 3rd and 7th day of hospital admission and in Group B on 1st day.Results: The study showed females have higher degree of hyperuricemia than males. SUA was significantly higher in patients of acute myocardial infarction than control group patients. SUA were also higher in patients with history of IHD, in patients with BNP >100 and it correlates with Killip class and mortality rates. Patients of acute myocardial infarction with diabetes mellitus had higher degree of hyperuricemia than nondiabetic and control group. No significant difference in SUA levels were observed with regard to age, alcohol intake, lipid profile, ejection fraction and hypertension.Conclusions: In acute myocardial infarction, patients with hyperuricemia had higher mortality and may be considered as poor prognostic biomarker.
ABSTRACT
Background: Obesity has reached epidemic proportions in India, affecting 5% of the country’s population. Urbanization and modernization has been associated with obesity in population of younger generation. The aim of the study was to find out variation in metabolic indicators (HDL, TG and anthropometric measurements) of normal overweight and obese undergraduate medical students. Methods: Total of 194 students took part in this study. Their height, weight and waist circumference were measured by standard methods. Their serum was estimated for HDL, TG and, fasting sugar on fully automatic Vitros 250 dry chemistry analyser from Orthoclinical diagnostics from Johnson & Johnson USA. Results: Over all females students were more overweight (Females 16% and Males 8%) and obese (F 18%, M 9%) as compared to males. Blood pressure, weight, waist circumference, HDL, and TG levels were more in overweight and obese group as compared to normal group. Conclusion: The results of the current study have shown an increasing trend of obesity and derangement of metabolic indicators among under graduate medical students.