ABSTRACT
Background and Aim: Pituitary adenomas are a part of a dissimilar group of benign neoplasms. The development of endoscopic techniques for surgery of paranasal sinuses has increased the opportunity for an endoscopic approach with regard to the pituitary gland. Minimally invasive endoscopic pituitary surgery, in turn, permits a more thorough tumor resection and fewer associated surgical complications. This study aimed to determine the descriptive outcomes and the complication rates for endoscopic transsphenoidal hypophysectomies
Methods and Materials/Patients: A prospective study was conducted from November 2012 to March 2015. 28 patients with proven symptoms of pituitary adenomas were included in this study, and regularly attended follow-up sessions
Results: In our study, we operated on 28 patients with hypophysis adenoma with the help of an endoscopic setting. The male to female ratio was 1:2.5, with average age range of 35 to 45 years. Growth hormone [GH] adenoma appeared in 36% [10 patients], prolactinoma in 21% [six patients], Cushing's disease in 18% [five patients] and non-functional adenoma in 18% [five patients]. Gonadotroph adenomas were the least common at about seven percent. The most common symptoms in our series were headache and visual defects. Five patients including two with prolactinoma and three with GH adenoma presented apoplexy signs and symptoms
Conclusion: Our series demonstrated that the endoscopic approach not only allows well anatomical visualization, and therefore facilitates the full oncological resection of tumors, but also reduces the incidence of pre-operative complications
ABSTRACT
Background and Aim: Low back pain is broadly documented as one of the most widespread pathologies in the advanced domain. Although the reasons of low back pain are uncountable, it has been meaningfully related to intervertebral disc degeneration. Present therapies for Intervertebral Disc [IVD] degeneration such as physical therapy and spinal fusion reduce symptoms' severity, but do not treat the source of degeneration. The use of tissue engineering to treat disc degeneration offers a chance to control the pathological course. New methods are presently being examined and have exposed mixed results. One major way of study has been stem cell injections. We go on to define the course of stem cell-mediated modalities in treatment of degenerative lumbar disc herniation
Methods and Materials/Patients: Literature search was performed in electronic databases PUBMED and EMBASE by means of Mesh terminologies [Nucleus pulposus, therapeutics, annulus fibrosus, intervertebral disc] and keywords [Degenerative disk disease, Stem Cells, Therapy]. Results: The intervertebral disc organization, developing treatments, mesenchymal stem cells, embryonic stem cells, practice in disc degeneration were some sections that were found in analysis for study review design
Conclusion: Mesenchymal stem cells [MSCs] have revealed potential in small animal models, nonetheless consequences in greater vertebrates have been varied
ABSTRACT
Background and Aim: Acute injuries of the spine and spinal cord are causing the greatest amount of disability. They produce high cost outcomes for patients and society psychologically and economically. Knowing the epidemiology of these injuries play an important role in planning for prevention and conservative treatment. But now, we have little information about this in our country. The aim of this study was to determine epidemiology of spinal injury in Sari Imam Khomeini hospital, main trauma center of Mazandaran, an Iranian province
Methods and Materials/Patients: The present cross-sectional study was conducted on all cases of traumatic spine injury, who were admitted in Sari Imam Khomeini hospital, main trauma center of Mazandaran, during 2012-2014. Checklist included demographic characteristics [age, gender, location], mechanism of injury of the spine, the level of injury detected by radiologic imaging and MRI and CT scans, the scoring systems for assessing the severity of injury that were American Spinal Injury Association [ASIA] scale and The Injury Severity Score
Results: Among a total of 906 cases, 57.8% [n=523] were male and 42.2% [ [n=383] were female. Male/Female ratio was 1.37:1. The most common age group at which spinal injury occurred in males was 25-44 years-old, and in females was 45-64 years-old [P=0.044]. The most frequent causative mechanism of trauma was traffic accidents [especially motorcycle-caused accidents]. The most common injury in spine fracture was compression and burst types. Among 93 patients with abnormal findings on neurological examination, 45 of them had complete spinal cord injury [class A of ASIA] and 48 of them had incomplete spinal cord injury [class B, C, D of ASIA]
Conclusions: Motor vehicles accidents are the most common cause of spine and spinal cord injury in Mazandaran,a region of the North of Iran. The incidence of spinal cord injury is high if ISS is more than 12