ABSTRACT
The objective of present study was to explore the hepatoprotective and antioxidant profile of Citrullus colocynthis fruits. Hepatoprotective profile of methanolic extract of Citrullus colocynthis fruits [MECCF] was investigated on rats, which were made hepatotoxic using paracetamol. The antioxidant profile of MECCF was evaluated by conducting Catalase, Super oxide Dismutase, Lipid Peroxidation and Diphenyl Picryl Hydrazyl tests. During hepatoprotective investigation, the Paracetamol treated group II showed significant increase in total bilirubin [TB], serum glutamate oxaloacetate transaminase [SGOT], serum glutamate pyruvate transaminase [SGPT] and alkaline phosphatase [ALP] level. The results so obtained showed that pretreatment of rats with MECCF 300mg/kg p.o. decreases the elevated TB, SGOT, SGPT and ALP serum levels. Also, MECCF inhibitory profile was found comparable with toxicant group [Paracetamol 2g/kg, p.o.]. The present study concludes that MECCF fruit possess significant hepatoprotective and antioxidant activity
ABSTRACT
Artocarpus altilis (Family: Moraceae) is commonly referred to as breadfruit as it is similar to freshly baked bread. Synonyms of Artocarpus altilis are Artocarpus communis and Artocarpus incisus. Basically Artocarpus species consists of phenolic compounds which include flavonoids, stilbenoids, arylbenzofurons and Jacalin, a lectin. Breadfruit (Artocarpus altilis) is originated from A. camansi Blanco (bread nut) which is native to New Guinea, Moluccas (Indonesia) and the Philippines. Many on-going researches are testing the pharmacological activities of Artocarpus altilis. Some of the researches that are being carried out on this plant includes antiinflammatory, antioxidant, antifungal, sexual behavior, immunomodulatory effect, antidiabetic effect and antibacterial effect. This review will help to provide detailed information on recent researches done on this plant.