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The aim of the present study was to assess the antipyretic activity of Siddha herbo-mineral formulation Surangusa Parpam at the dose level of 15mg/kg and 35mg/kg body weight, orally, in brewer yeast induced fever model Wistar rats. Fever was induced by subcutaneous injection of 10ml/kg of 20% w/v aqueous suspension of brewer’s yeast into the nape of the rat's neck. After eighteen hours feverish animals were treated with Surangusa Parpam 15mg/kg and 35mg/kg body weight, orally, and rectal temperatures were evaluated at 0, 1, 2 and 3 hours post-treatment by inserting a well-lubricated bulb of the clinical thermometer. Surangusa Parpam showed a significant decrease in the elevated body temperature of rats that remained sustained throughout the tested time points from 1 to 3 hours in the used model. 35mg/kg body weight dose level showed significant inhibition of elevated body temperature when compared with the standard control. These results indicate that the Antipyretic activity of Surangusa Parpam and in addition to its well-established anti-inflammatory activity possesses significant antihistamine activity that may be beneficial in symptomatic relief when it is used in the therapy of allergic and inflammatory disorders.
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The impact of Alzheimer's disease on the population is signi?cant. Alzheimer's disease rose from the 25th most burdensome disease in the world. In order to identify depth and importance of the disease a scientometric study has been carried out. The study was carried out with the objective to examine the cited publications in Alzheimer's disease research and to examine the chronological growth of cited publications. The literature on Alzheimer's disease research data has been downloaded from 'Scopus', multidisciplinary online database, which is an international indexing and abstracting database, using the search term “Alzheimer's”. A total of 1,79,722 records have been identi?ed during the period of 1970-2017 (48 years). The study was carried out with the objective to examine the cited publications in Alzheimer's disease research and to examine the chronological growth of cited publications. Further study identi?es the authorship pattern of cited publications. The data were analysed based on trend of Cited publications; Citation and type of access; Yearwise growth; Block yearwise; Authorship pattern and Document type of cited publications. Nearly 85.3% of publications were cited and only 14.7% of publications were uncited. The study reveals that the citation of articles gets study increase every year during the study period and seems to be in linear trend. Nine papers out of 10 papers get cited irrespective of document type except short survey.
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Background: The objective of the study was to evaluate the anticonvulsant activity of nicardipine in wistar albino rats.Methods: Anticonvulsant activity of nicardipine in a dose 10 mg/kg, and its effect with the standard drug lamotrigine (5 mg/kg) was studied in a maximal electroshock seizures (MES) experimental animal model.Results: Nicardipine in dose of 10 mg/kg showed significant anticonvulsant effect (p<0.001) and combination with standard drug lamotrigine (p<0.001) also showed more significant anticonvulsant effect in MES model.Conclusions: Nicardipine is having anticonvulsant activity and it also potentiates the anticonvulsant effect of lamotrigine in MES model.
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Background: The objective is to study the fetomaternal outcome in teenage pregnancy at MGMGH for the study period of 6 months from April 2018 to September 2018. Teenage pregnancy is a worldwide health problem. WHO defined adolescence as the period from 10-19 years. It is a serious health problem in a developing country like India. Teenage pregnancy is associated with high risk of prematurity, low birthweight, preeclampsia and anaemia. The NHFS IV 2015 -2016 estimates that overall teenage pregnancy in India 7.9%.Methods: It is a retrospective study conducted in a tertiary care hospital at MGMGH, Trichy over a period of 6 months.251 teenage pregnant women delivered at our institution were selected for the study out of 4508 total deliveries during the study period. Parameters including incidence, age, parity, booking status, educational and socioeconomic status, medical disorders, antepartum, intrapartum, postpartum complications, mode of delivery and neonatal outcome were studied.Results: Study showed the incidence of teenage pregnancy at our MGMGH is 5.56%. Among these teenage pregnant women 47.1% had anaemia, 23.1% had gestational hypertension,4.8% of women had eclampsia, 22.3% % had preterm delivery. Lscs rate was 27.1%,70.29 % had Normal vaginal delivery,1.6% had instrumental deliveries, 31.5% had low birth weight babies,28.2 % NICU admissions, 2.9% perinatal deaths.Conclusions: Teenage pregnancy is associated with increased incidence of anaemia, pre-eclampsia, eclampsia, preterm delivery, instrumental delivery, low birth weight and perinatal death. By improving socio economic status, education, nutrition, good antenatal care, public awareness, institutional delivery and postnatal care help in reducing maternal and perinatal morbidity and mortality in adolescent pregnancy.
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Background: Siddha medicine is one of the oldest herbal medication after Ayurveda. For many centuries, siddha medicine is being used to cure or prevent many diseases including cancer. MahaVellathyLehyam is one such Siddha medicine possessing characteristic nature against cancer. The main objective of this study is to explicate the potential of MVL as a chemopreventive agent by analysing the alterations in lipidperoxidation, membrane bound enzymes and glycoconjugates against 4-Nitroquinoline-1-oxide (4NQO) induced rat oral carcinogenesis. Materials and methods: The male wistar rats were subjected to the carcinogen 4NQO and the activity of MVL against the carcinogenic cells was studied through lipid peroxidation, membrane bound ATPases (Na+ /K+ ATPase, Ca2+ ATPase and Mg2+ ATPase) and protein bound carbohydrate components (protein bound hexose, hexosamine, sialic acid and fucose). Results: The obtained result was visualized as an increase in the expression of the lipid peroxidation of the tongue tissue, membrane bound ATPases and glycoconjucates indicating oxidative stress induced by the carcinogen 4QNO. Priyanka G, Kayalvizhi E, Madan Kumar A, Chinmayi Sri Amulya Y, Rajajeyakumar Manivel. Chemopreventive effect of Maha Vallathy leghiyam on 4-Nitroquinoline-1-oxide induced oral carcinogenesis in wistar rats. IAIM, 2019; 6(7): 28-36. Page 29 Conclusions: The administration of MVL has caused a significant decrease in these aspects suggesting the nature of MVL against the carcinogenic nature of 4NQO by efficiently decreasing the oxidative damage.
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Dental caries is a multifactorial disease in which microorganisms play an important role. Recently, herbs have been tried as mouthrinses to combat the side effects of chemical mouthrinses. The anticaries efficacy of Sodium fluoride, Tulsi leaf, and Black myrobalans fruit extracts on Streptococcus mutans (S. mutans) have been reported in the literature, but no comparative study has been done yet. Aim: This study aims to observe the change in the pH of saliva and to assess the efficacy of the herbal rinses-Tulsi and Black myrobalans on S. mutans count while comparing it with Sodium fluoride mouthrinse. Methods: Herbal ethanolic extracts of Tulsi (4%) and Black myrobalans (2.5%) were prepared as mouthrinses and compared with sodium fluoride mouthrinse (0.05%). Sixty high caries risk patients were selected and allocated randomly into three groups [n = 20], categorized as Group A-Sodium fluoride mouthrinse, Group B-Tulsi mouthrinse, and Group C-Black myrobalans mouthrinse. They were instructed to rinse their mouth with their assigned mouthrinses for 7 days. Salivary samples were collected and sent to the laboratory at baseline, 1 h postrinsing and after 7th day of rinsing for determining the salivary pH and S. mutans count. The increase in pH and reduction of S. mutans were determined. The values obtained were tabulated and statistically analyzed. Results: There was a significant increase in the salivary pH and reduction in S. mutans count after rinsing in all the three groups. Increase in salivary pH was more in the Sodium fluoride mouthrinse when compared to the experimental herbal groups (Group B and Group C). While S. mutans counts reduced more with Tulsi mouthrinse at 1 h postrinsing and after the 7th day of rinsing more reduction was seen in Black myrobalans mouthrinse group. Conclusion: The results of the study suggest that herbal mouthrinses could be tried as an adjunctive anticaries agent against dental caries causing microorganisms.
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Background: Control of post-operative pain is a major concern for the patients and also for the treating physicians. Various analgesic agents such as opioids, nonopioids through various routes such as oral, intravenous, neuraxial, regional for the management of postoperative pain exist. Magnesium has anti-nociceptive properties with additional enhancement of opioid anti-nociception when used epidurally. Materials and methods: The study was a randomized open labelled controlled trail, conducted in the department of anaesthesiology, Govt. Mohan Kumaramangalam Medical College and Hospital, Salem, Tamil Nadu. The data collection for the study was done between June 2016 to June 2017. The study population included people who were undergoing lower limb surgery for various disease conditions. The key outcome variables assessed were highest sensory blockade, time taken for highest sensory level (min), duration of surgery (min), time for regression to L1 (min), duration of analgesia (min). Results: Duration of analgesia was longer in the Magnesium sulphate group, with analgesia lasting for 143.4 +39.57 minutes which was statistically significantly higher compared to Epidural Fentanyl group with 107 (±25.82) minutes. The mean time for regression to L1 was 118 minutes and 119 minutes in group F and FM respectively, there is no statistically significant between two study groups (P value>0.05). There was no statistically significant difference between the groups in the time taken J. Radhika, P. Kayalvizhi. Comparative study of epidural fentanyl and epidural fentanyl with magnesium sulphate for postoperative analgesia in patients undergoing lower limb surgeries. IAIM, 2018; 5(2): 12-19. Page 13 for the highest sensory level (P value>0.05), the duration of surgery and the time taken for the highest sensory level (P value>0.05). Conclusion: Magnesium being a relatively harmless and inexpensive molecule, a non-competitive, Nmethyl-D-aspartate receptor antagonist with its anti-nociceptive properties has a huge role to play in the coming years for postoperative analgesia
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Background: Adding a small-dose of ketamine provides better postoperative analgesia and reduces morphine consumption after major abdominal surgery. Psychomimetic effects are the most troubling side-effects of ketamine. Hence evaluation of the safety and efficacy of adding ketamine to epidural bupivacaine with morphine is the need of the hour. Materials and methods: The study was a randomized controlled trial conducted in the Department of Anesthesia, Department of Anesthesiology, Government Mohan Kumaramangalam Medical College and Hospital between April 2015 to March 2016. Study on 60 subjects of ASA I and II category randomized into two groups undergoing elective abdominal surgeries was done. 30 subjects in the study group received ketamine 0.2 mg/kg in addition to epidural morphine 0.05 mg/kg with 0.125% bupivacaine alone received in the control group for post-operative analgesia. The subjects were monitored for 24 hours. Results: The mean time for onset of analgesia and median duration of analgesia was 6.10 ± 1.27 minutes, 13.73 ± 3.10 hours respectively in ketamine group (Group I) whereas it was 12.53 ± 2.08 minutes, 8.27 ± 1.08 hours respectively in the control group. There was no complication or ketamine related side effects in the ketamine group compared to one in the control group.
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Benzidine based azo dyes are proven carcinogens, mutagens and have been linked to bladder cancer of human beings and laboratory animals. The textile and dyestuff manufacturing industry are the two major sources for releasing of azo dyes. Various research groups have started work on genotoxic effect of textile dyes in occupational workers of textile dye industry. Bladder cancer is the most common form of cancer in dye industries. Most of people between age 50 and 70 group of are diagnosed with bladder cancer. Men are more likely than the women to develop bladder cancer. Bladder cancer is a disease in which abnormal cells multiply without control in the bladder. The most common type of bladder cancer begins in cells lining the inside of the bladder and is called transitional cell carcinoma. Tumor markers are substances that can be found in the body when cancer is present. They are most often found in the blood or urine. The review deals about the impacts of the industry dyes on human health.
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BACKGROUND AND OBJECTIVE: The purpose of this investigation was to estimate the impact strength of fractured anterior teeth reattached using three different restorative materials and compare their impact strengths to those of control. MATERIALS AND METHODS: Sixty human maxillary permanent central incisors were selected and divided into control and experimental groups. The teeth in the experimental groups were fractured and then bonded using Composite resin, Compomer and resin-modified GIC. Intact teeth served as control. All the specimens were then tested in an impact testing machine. RESULTS: The results revealed statistically significant differences between Compomer and resin-modified GIC groups, control and experimental groups. No statistically significant differences were observed between Composite resin and Compomer groups. CONCLUSION: Thus the fractured fragments bonded with Composite resin and Compomer provided better adhesion than resin-modified GIC.