ABSTRACT
OBJECTIVE To investigate the trend of distribution and drug resistance of clinical isolates of Enterobacter cloacae during the last three years in our hospital. METHODS Strains collected from daily specimens were identified and drug resistantce with SENSITITRE bacteria analysis system. RESULTS The most strains were isolated from samples of sputum,urine,nad other excretion. The drug resistance rates to imipenem and cefepime were less than 32%. Cefoxitin,ampicillin and cefazolin were ineffective to contralE. cloacae. The drug resistance rates to penicillins,cephalosporins,chloramphenicol and aminoglycoside antibiotics increased more than 20% in last three years. CONCLUSIONS E. cloacae is multiple-resistant to antibiotics and displays higher levels of antibiotic resistance. It is suggested that antibiotics be used reasonably under the guidance of antibiotic susceptibility testing.