ABSTRACT
Background: Stroke is a multifactorial disorder, the most common cause being arterial occlusion
Transcranial Doppler Ultrasonography [TCD] is a common non-invasive method available for assessment the arterial blood flow of the brain
Objective: Assessment the hemodynamic parameters of cerebral arteries, using TCD device in patients suffering ischemic stroke
Materials and Methods: This descriptive cross-sectional study was conducted on patients with ischemic stroke in 2014 in Iran after being approved by ethics committee of Researches and Technology Vice-chancellorship of Guilan University of Medical Sciences. After obtaining informed consent, all patients underwent TCD. Demographic details and TCD findings were recorded. Data were analysed in SPSS software 21 using independent t-test, Chi-square, and Fisher's exact tests. The descriptive results were presented as mean +/- SD and frequency
Results: A total of 102 patients [69 men and 33 women] with ischemic stroke and mean age of 63.72 +/- 12.64 years participated in this study
Among 49.02% of patients at least one hemodynamic abnormality was diagnosed. Small Vessel Disease [SVD], extracranial stenosis [ECS] and intracranial stenosis [ICS] were found in 29.41%, 20.59% and 11.76% of patients respectively
Abnormal Pulsatility Index [PI], Peak Systolic Velocity [PSV] and Mean Blood Flow Velocity [Vm] were reported in 32.25%, 20.59% and 9.8% of them respectively. A significant relationship was found between PSV parameter and also presence of ECS and gender [p = 0.047]
Moreover, SVD and abnormal PI were found significantly related to age [p - 0.002]
Conclusion: TCD results showed almost half of the patients with ischemic stroke were found to have at least one hemodynamic abnormality
ABSTRACT
Background: Intracerebral Hemorrhage [ICH] is a stroke type which resulted in disability. Memantine have been supposed to have the effect on the functional status in patients with ICH
Objectives: Comparing the effect of memantine with placebo on the clinical outcome of ICH
Materials and Methods: This double-blind clinical trial was conducted in an academic hospital in northern Iran on patients with ICH allocated in memantine and placebo group through the random block method
The patients' neurological status was assessed on admission, the seventh day, upon discharg and ultimately three months after the ICH onset, according to the Nationa Institute of Health Stroke Scale [NIHSS], modified Rankin Scale [mRS] Barthel Index [BI] and Glasgow Coma Scale [GCS]
The data analysis was done by using independent t-test, Chi-square and repeated measure tests SPSS software version 21
Results: A total of 64 patients have been allocated into two equal size group! with no significant differences in terms of age or gender [p>0.05]
The meal increase in the BI and the decrease in the mRS were significantly greater in tW memantine group compared with the placebo group as measured fron admission time until three months following the ICH onset [p=0.001 anc p=0.049, respectively]
No significant differences were observed between the two groups in mortality rate [p=QA92] and the means and changes of the GCS [p=0.331] and the NfflSS score [p=0.211]
Conclusion: Early administration of memantine to ICH patients can result ii significant improvement of long-term motor function and functional independence