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Chinese Journal of Experimental and Clinical Virology ; (6): 72-74, 2006.
Article in Chinese | WPRIM | ID: wpr-305521

ABSTRACT

<p><b>BACKGROUND</b>To investigate epidemiology and HLA typing of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China.</p><p><b>METHODS</b>This was a cohort study for epidemiologic characteristics of highly exposed but persistently seronegative subjects. PCR with sequence-specific primer and PCR-SSP for HLA typing were applied.</p><p><b>RESULTS</b>Eight HEPS were identified. Compared HLA typing with seropositive couple, high frequency of HLA-a24, HLA-B40 genotyping was observed.</p><p><b>CONCLUSION</b>Highly exposed to HIV but persistently seronegative subjects in commercial blood donors in China had high frequency of HLA-A24 and HLA-B40 genotype.</p>


Subject(s)
Adolescent , Adult , Female , Humans , Male , Middle Aged , Young Adult , Blood Donors , China , Epidemiology , Cohort Studies , HIV , Allergy and Immunology , HIV Antibodies , Blood , HIV Infections , Epidemiology , Virology , HIV Seronegativity , HLA Antigens , Genetics , HLA-A Antigens , Genetics , HLA-A24 Antigen , Histocompatibility Testing , Methods , Polymerase Chain Reaction
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