ABSTRACT
Objective To study the application effect of minocycline in the treatment of aggressive periodontitis.Methods From January 2014 to January 2017,116 cases of invasive periodontitis in the People's Hospital of Panan County were selected in the research.According to the different treatment methods,the patients were divided into observation group and control group with 58 cases in each group.The control group was given basic treatment,the observation group was given minocycline on the basis of basic treatment.The levels of tumor necrosis factor α(TNF-α),interleukin-17(IL-17),matrix metalloproteinase-1(MMP-1)and matrix metalloproteinase-8(MMP-8)in the two groups were observed.The changes of gingival index(GI),periodontal exploration depth(PD),attachment loss(AL),periodontitis gingival crevicular fluid(NO)were compared.Results After treatment,the total effective rate in the observation group was 93.1％(58/54),which was significantly higher than that in the control group [80.0％(58/46)],the difference was statistically significant(χ2 =9.469,P=0.002).After treatment,the levels of TNF-α,IL-17,MMP-1,MMP-8 in the gingival crevicular fluid of the observation group were(2.98 ±0.77)ng/mL,(20.87 ± 5.34)pg/mL,(1422.45 ±175.45)pg/mL,(1341.58 ±169.56)pg/mL,respectively,which were lower than those of the control group[(3.98 ±0.99)ng/mL,(31.65 ±7.88)pg/mL,(1781.44 ±199.55)pg/mL,(1678.99 ± 185.44)pg/mL](t=6.072,8.625,10.289,10.226,P<0.05).The levels of GI,PD,AL and NO of the observation group were(1.21 ±0.38)mm,(1.51 ±0.61)mm,(2.43 ±0.39)mm,(45.78 ±8.21)μmol/L,respectively,which were lower than those of the control group [(3.31 ±0.29)mm,(4.21 ±0.89)mm,(3.59 ±0.62)mm,(64.34 ± 12.88)μmol/L](t=33.4572,19.057,12.061,9.254,all P<0.05).After treatment,the levels of TNF-α,IL-17,MMP-1 and MMP-8 in the gingival crevicular fluid of the two groups were significantly lower compared with those before treatment(observation group:t=14.590,18.885,23.019,3.789,control group: t=7.809,12.993,10.905,7.608,all P<0.05).Conclusion The use of minocycline in the treatment of invasive periodontitis can significantly reduce the levels of TNF-α,IL-17,MMP-1,MMP-8 in gingival crevicular fluid,relieve periodontal plaque,promote periodontal tissue regeneration,the clinical efficacy is good.