ABSTRACT
Inflammation is a protective biological reaction against infection and has undesirable effects. Although bergenin (BG),a C-glycoside derivative of 4-O-methyl gallic acid, has many pharmacological properties, no study has demonstratedthe activity of BG in inflammatory mediators, such as histamine and prostaglandin E2 (PGE2). The present studyinvestigated the anti-inflammatory activity of BG obtained from Peltophorum dubium Taub, in edema models inducedby carrageenan and inflammatory mediators in Swiss mice. The assessment of its toxicity was also conducted. Theevaluations of this study indicated that the pre-treatment with BG (25 mg/kg) significantly reduced edema induced bycarrageenan, compound 48/80, histamine, and PGE2 (p < 0.05). Also, pre-treatment with BG inhibited the recruitmentof leukocytes and neutrophils, reducing adhesion and rolling of these cells, myeloperoxidase (MPO) activity,malondialdehyde (MDA) levels, and vascular permeability. Treatment with BG (2,000 mg/kg) showed no toxicsigns in hippocratic screening, weight of animals, water and feed intake, vital organs weight and histopathologicalevaluation, and hematological and biochemical parameters. In conclusion, these results show that the BG obtainedfrom P. dubium Taub has anti-inflammatory activity against different models of inflammation, reducing neutrophilmigration and damage caused by oxidative stress and lipid peroxidation. BG did not present toxic effects in theevaluated parameters.