ABSTRACT
Objective To studythe effects of prolacfin(PRL)on uterineleiomyoma and the relationship between prolactin and prolaetin receptor(PRL-R).Methods Thirty patients with uterine leiomyoma as observed group and thirty with hydrosalpinx or pyosalpingitis a8 control group were studied.Serum prolaetin(PrL),estradiol(E2)and progesterone(P)level were determinted by radioimmunoassay before,during and three months after hysterectomy in observed group and before salpingectomy in control group.Results Serum prolactin levd in observed group was signifieantly higher than that in control group(P＜0.05).The serunl prdactin level of uterine veins in obserced group was significantly higher than that ofperipheral vein' during hysterectomy(P＜0.05).The prolactin level during hysterectomy in observed group is significantly higher than that before hysterectomy(P＜0.05).Three months after hysterectomy the serum prolactin and estradiol level of peripheral vein in observed group was significantly decreased(P＜0.05).Conclusion Prolaetin is an autoerine or paraerine growth factor for human myometrial and leiomyoma cells.