ABSTRACT
Background: disorder of testosterone [T] biosynthesis and decline of serum level had reported in systemic inflammatory rheumatoid arthritis disease and with less frequency in chronic obstructive pulmonary disease and a few other pulmonary diseases. However, no known study has performed about sulfur mustard[SM] induced asthma in Iranian veterans. The aim of study was to assess status of hypogonadism and free serum T levels in SM induced asthma and to compare with healthy subjects
Materials and Methods: protocol of study based on random selection of target population among SM induced diseases by self- report questionnaire, male, physician- diagnosed asthma, and positive history of SM exposure. Healthy subjects enrolled according to age sex- matched as a control
Results: thirty-three chemical victims had mean age 53.39 +/- 6.69 SD years. Mean serum free T level was 15.98 +/- 10.52 SD. 30.6% had below the lower normal range. Moreover, means serum values of Follicle stimulating hormone [FSH], Latinizing hormone [LH], Dehidroepianderstone [DHEA] were 11.70 +/- 9.45 SD, 10.40 +/- 7.65 SD, and 1.32 +/- 0.70 SD respectively. Mean free T level of 39 healthy subjects were 23.45 +/- 8.31 SD. The independent samples T test was performed between SM induced asthma and normal groups. Highly Significant differences were founded between free serum T levels among SM induced asthma and normal subjects [P<0.001]
Conclusion: the highly significant frequency of hypogonadisem observed in SM induced asthma group. It may be due to stress of chemical war, influence of glucocorticoid usage, and toxic effect of SM on spermatogenesis. Further studies will suggest carrying out in future years
ABSTRACT
Background: Chemical victims who have a history of exposure to sulfur mustard gas comprise considerable number of our young population. To evaluate the rate of osteoporosis in a group of asthmatic victims of sulfur mustard gas and to compare it with non-chemical asthmatic patients, in order to determine the distribution, site of involvement, intensity of effects, and difference or indifference with non-exposed group
Materials and Methods: In this prospective study, 100 asthmatic male patients who had a history of exposure to sulfur mustard gas were selected according to inclusion and exclusion criteria, and matched with 100 non-chemical asthmatic male patients as to age, duration of disease, duration of cotrticosteroid therapy, and the form of therapy. Bone Mineral Density [BMD] test was performed on hip and lumbar vertebras in case and control groups evaluated in accordance to WHO criteria. Independent- sample T test was used to analyze the results
Results: There is a significant difference [p<0.05] between the two groups in the range of osteoporosis and osteopenia. No significant correlation was found between age and complications. Most changes [65%] were observed in the vertebral column, and hip involvement [%5] was much more severe in the case group
Conclusion: Considering the morbidities caused by this chemical warfare agent, the osteoporotic complications in chemical victims can intensify their disabilities. Therefore, preventive measures must be undertaken to reduce complications
ABSTRACT
Background: Chemical victims who have a history of exposure to sulfur mustard gas comprise considerable number of our young population. To evaluate the rate of osteoporosis in a group of asthmatic victims of sulfur mustard gas and to compare it with non-chemical asthmatic patients, in order to determine the distribution, site of involvement, intensity of effects, and difference or indifference with non-exposed group
Materials and methods: In this prospective study, 100 asthmatic male patients who had a history of exposure to sulfur mustard gas were selected according to inclusion and exclusion criteria, and matched with 100 non-chemical asthmatic male patients as to age, duration of disease, duration of cotrticosteroid therapy, and the form of therapy. Bone Mineral Density [BMD] test was performed on hip and lumbar vertebras in case and control groups evaluated in accordance to WHO criteria. Independent- sample T test was used to analyze the results
Results: There is a significant difference [p<0.05] between the two groups in the range of osteoporosis and osteopenia. No significant correlation was found between age and complications. Most changes [65%] were observed in the vertebral column, and hip involvement [%5] was much more severe in the case group
Conclusion: Considering the morbidities caused by this chemical warfare agent, the osteoporotic complications in chemical victims can intensify their disabilities. Therefore, preventive measures must be undertaken to reduce complications