ABSTRACT
Chronic recurrent aphthous stomatitis(CRAC) is a chronic disease of the oral mucosa, characterized by periodic remissions and exacerbations with the eruption of aft. According to WHO, it affects up to 20% of the population. Currently, most scientists are inclined to the leading role of the immune system in the pathogenesis of the disease. It has been established that with increasing severity of the disease T-suppression of immunity increases, which is characterized by a decrease in the number of T-lymphocytes and their functional activity. The increase in the number of T-suppressor cells accompanied by a decrease in the number of T-helper cells. The severity and duration of the disease correspond to the severity of the sensitization of the body with these antigens. The work was carried out based on scientific-educational practical dental center at the Bukhara State Medical Institute of Therapeutic Dentistry. A clinical examination of 67 patients aged 25–35 years with chronic recurrent aphthous stomatitis was conducted, 14 healthy individuals were included in the control group
ABSTRACT
Recent studies indicate that oral health of the human population, unfavorable trends persist. Despite several researches conducted both in Uzbekistan and abroad, the etiology and pathogenesis of recurrent aphthous stomatitis remains unexplained. The aim of the study is to assess the clinical status of patients with recurrent aphthous stomatitis and develop a method of treatment and prevention. Methods: 106 patients with recurrent aphthous stomatitis were diagnosed. The frequency of exacerbations of RAS ranged from 1 to 4 or more relapses per year, the duration of the disease was more than one year. Results: 72.2% of cases (44 people) were women aged 18-29 years, among men a greater number of complaints - 17 (27.8% cases). Disease duration of recurrent aphthous stomatitis in the patients participating in the study averaged 5.17±0.38 years. 41 people suffered from RAS 1 to 3 years. In 38 patients, the disease duration ranged from 3.1 to 5 years, in 12 people, RAS was observed from 5.1 to 7 years, 15 patients suffered from the pathology under study for more than 7 years. Conclusions: Timely early diagnosis of RAS is not only completely cure for patient, avoid complications, but also revise the low efficiency of traditional methods of the treatment.