ABSTRACT
Introduction: Cancer of the esophagus is a fatal disease and ranked the 6th most common cause of cancer-related deathworldwide. Treatment for esophageal carcinoma is characterized as curative or palliative. Data from different studies showonly 20% of patients present with cancer of the esophagus that is truly localized to the esophagus, indicating that at the timeof diagnosis, approximately 80% of patients have either locally advanced or distant disease.Aim: This study aims to study the clinical assessment of quality of life (QOL) before, during, and after treatment of concurrentchemoradiotherapy in inoperable esophageal cancers.Materials and Methods: A single-arm prospective study of patients undergoing definitive chemoradiation treatment for locallyadvanced esophageal carcinoma was included in the study. All patients will have to undergo QOL assessment by the EuropeanOrganisation for Research and Treatment of Cancer questionnaire before, during, and after treatment.Results: A total of 40 patients were included in the study. Among the functional scales, emotional functioning, cognitivefunctioning, role functioning, physical functioning, and anxiety show a significant positive mean difference. This indicates ahealthy level of functioning after treatment.Conclusion: Definitive concurrent chemoradiation with cisplatin and 5-fluorouracil (FU) was well tolerated, promising a reasonabletherapeutic option for patients with inoperable locally advanced esophageal squamous cell carcinoma.