ABSTRACT
Th e oral cancer is major health problem worldwide with the incidence of 500,000 new cases per year and considered as 4th most common cancer in world and 1st in India. Among all oral squamous cell carcinoma (SCC) is reported to be the most common malignant tumor involving oral cavity which is commonly associated with tobacco chewing habit in India and other parts of Asia and smoking habit in western countries. Oral leukoplakia is a white, non-scrapable, keratotic lesion in the oral mucosa which represents the most prevalent precursor lesion of oral SCC hence clinical diagnosis of oral leukoplakia associated with tobacco habit is very important for the prevention of oral cancer. Here, we report a case of oral SCC, which was reported to be transformed from existing oral leukoplakia lesion.