ABSTRACT
Backgrounds and Objectives: Very few analytical studies are available on any association between Colorectal Cancer [CRC] among diabetic patients compared with non-diabetic subjects at least in Iran. The aim of this case control study was to determine the risk of CRC in type 2 diabetic patients
Materials and Methods: In this study, 207 CRC cases, who had positive results by colonoscopy and biopsy, from Colonoscopy units in Tabriz Referral hospitals and 207 controls, gender and age matched had negative colonoscopy and biopsy results, was selected from the same centers with no history of any malignant tumor and nonneoplastic, Data were collected by questionnaires, and entered into the SPSS19. Multivariate logistic regression was used to estimate odds ratios adjusting for diabetes and risk of CRC
Results: of 414 patients studied, 194 [47%] females and 220 [53%] patients were men. The mean age and Body Mass Index [BMI] of patients was respectively, 59.52 +/- 13.8 and 26.47 +/- 3.8 Kg/m2. Of 207 patients with colorectal cancer, 48 patients were diagnosed with diabetes in contrast of 207 controls only 21 patients were diagnosed with diabetes. The final analyses indicate that diabetes increase the risk of CRC. [OR: 2.57, %95 CI: 1.25-4.58, P=0.006]
Conclusions: Our findings indicate that Diabetes increase the risk of CRC
ABSTRACT
There is some evidence that leukocytosis without infection is associated with increased hospital mortality, but data in this regard are very incomplete. This study was designed to investigate the relationship between leukocytosis at the time of admission and mortality among patients hospitalized in general wards. During July to Nov 2004, all deceased patients who had a white blood cell [WBC] count record for the first 24 hours of admission were selected as cases. Among survivors, twice the number of cases was selected as controls. Different levels of WBC counts were compared between cases and controls. Totally 1650 patients, including 550 deceased [cases] and 1100 survivors [controls] were analyzed. Of these, 876 [53%] were males and 774 [47%] females, and 42 [3%] were admitted to ICU, 1426 [86%] to medical and 182 [11%] to surgical wards. There was a significant difference between the mean age of deceased patients [78.0 years] and survivors [53.0 years] [P<0.001]. The median WBC for deceased and surviving patients was 9.4 and 11.4 x 10 [9] /1, respectively. Patients with a WBC > 10x10 [9]/1 accounted for 804, among which 335 [42%] were deceased. Leukocytosis and leucopoenia were more frequent among the deceased patients compared to the survivors. The likelihood ratio for leukocytosis and leucopenia among the cases and controls was 1.4 and 2.3, respectively. Leukocytosis was identified as an alarming sign for mortality among patients admitted to general hospital wards at early stages of admission. A quick medical intervention for amendment of the causes related to leukocytosis should consequently reduce hospital mortality