1.
Mansoura Journal of Pharmaceutical Sciences. 1998; 14 (1): 71-87
in English
| IMEMR
| ID: emr-48634
ABSTRACT
This study investigated the mechanism by which anhydrous calcium phosphate [A-TAB] exhibits its sustained release matrix, via premixing of A-TAB [diluent] powder with different excipients, e.g. Avicel, sodium alginate and polyvinyl alcohol [PVA], to block entrapment sites if any, on the dissolution of theophylline from A-TAB tablets. Furthermore, the inclusion of other excipient [palmetic acid] to impart a more acid resistant character on the diluent/drug blend and thus assist in maintaining the matrix structure of A-TAB were also investigated. The rate and extent of drug dissolution were dependent on the order of mixing of A-TAB with the drug and excipient as well as the pH of the dissolution medium
Subject(s)
Calcium Phosphates/pharmacokinetics , Delayed-Action Preparations , Drug Design , Polyvinyl Alcohol , Palmitic Acids , Theophylline
2.
Alexandria Journal of Pharmaceutical Sciences. 1997; 11 (3): 139-144
in English
| IMEMR
| ID: emr-43897