ABSTRACT
Background:Dengue epidemics are more frequent in developing countries like India. Dengue is a self-limiting disease but its complication in children may cause high morbidity and mortality. Objective: The main objective of this study was to assess the clinical profile of dengue fever in children less than 15 years of age. Methods:This was a retrospective study done in a pediatric department of Maharishi Markandeshwar institute of medical science and research hospital, Ambala, a university level medical college of North India for a period of 17 months.Results:A total of 130 patients of dengue fever were identified in our study. Out of these 130 patients, 39 patients were included in dengue without warning signs,78 were included in dengue with warning signs and 13 insevere dengue category. The most common age group was between 5 to 10 years of age. Fever was the most common presenting symptom in all dengue patients. No mortality was observed during our study period due to dengue.Conclusions:It is one of the dreaded fevers for all the pediatric age group. So, early suspicion and effective management can reduce the severity.
ABSTRACT
Background: There is a high incidence of alloimunization in many patients with diseases that require repetitive blood transfusions. One such group is chronic renal failure patients as majority of them have severe anemia due to deficiency of erythropoietin. As many such patients are unable to afford erythropoietin, they are treated with blood transfusions. This study was thus undertaken to study alloimunization in such patients at our center.Methods: A total of 96 patients found eligible were enrolled in this cross-sectional study that was carried out from June 2016 to august 2016. After detailed history, antibody screening was done by using Immucor Panoscreen three vial set and if screening came out to be positive antibody identification was then done by using Immucor Panocell-10.Results: 96 patients including 76 male and 20 female patients recieved a total of 912 transfusions. Alloantibodies were detected in a total of 12 patients (12.5%). Of these 12 patients 8 patients had a single antibody whereas 4 patients developed two antibodies. The antibodies developed at a rate of 1.8% per transfusion (16/912). On alloantibody type identification, the most common type found was anti E (4/16) followed by both anti D and anti C in 3 patients each.Conclusions: Alloimmunization to minor erythrocyte antigens occurs in many patients of chronic renal failure. This results in frequent pre-and post-transfusion complications. Inclusion of antibody screening test in routine pretransfusion testing protocol for the patients who are at higher risk of alloimmunization and require long-term transfusion dependence is desirable.