Anti-cancer activity of three terminalia species and preliminary phytochemical screening

This study evaluated anticancer potential of three Terminalia species, Terminalia muelleri, Terminalia bellerica, and Terminalia laxiflora and also their phytochemical content were determined. Anticancer potential of the plant extracts was measured according to MTT assay. The results showed that T. muelleri methanolic extract was active against breast cancer cell line with IC[50] 40 microg/mL. T. bellerica methanolic extract exerted cytotoxic effects only against colon cancer and liver cancer cell lines with IC[50] of 50 and 15microg/mL, respectively. While T. laxiflora methanolic extract did not inhibit the proliferation of all cancer cell lines tested. Phytochemical investigation of the three plant species proved the presence of carbohydrates, flavonoids, tannins, and triterpenes. The methanolic extracts of T. muelleri and T. bellerica had a significant anticancer activity and so further phytochemical study to isolate and identify the bioactive molecules responsible for the observed anticancer activity is necessary

Effect of aqueous extract of Solanum xanthocarpum Schrad. & Wendl. on postmenopausal syndrome in ovariectomized rats / 中西医结合学报

<p><b>OBJECTIVE</b>Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) is present in many Ayurveda compound formulations including Chavanaprasha and Dasamoolarishta. The whole plant is used in conditions such as inflammation, constipation and promoting conception in females. In the present study, we carried out different tests to evaluate the effect of aqueous extract of Solanum xanthocarpum (SXE) in postmenopausal syndrome.</p><p><b>METHODS</b>The study was carried out in bilaterally ovariectomized one-month-old Wistar rats (40-50 g). Bilaterally ovariectomized (OVX) Wistar rats were divided into four groups (n=6) receiving different treatments, consisting of a vehicle (distilled water), aqueous extract of Solanum xanthocarpum at two different doses (200 and 400 mg/kg) administered orally daily for 90 d and standard drug β estradiol at a dose of 1 mg/kg administered subcutaneously biweekly for 90 d. Estrogenic activity was assessed by vaginal cornification, sexual behavior, serum estradiol and uterine weight to body weight ratio. Antiosteoporotic activity was assessed on the basis of biomechanical and biochemical parameters followed by histopathological studies, and antidepressant activity was assessed by forced swim test.</p><p><b>RESULTS</b>SXE showed presence of steroids. At the dose of 200 mg/kg, it significantly improved all the parameters of sexual behavior (P<0.01), caused vaginal cornification, and increased serum estradiol and uterine weight (P<0.01). It also significantly improved all the parameters of bone strength as well as depression (P<0.01). Histopathology of bones confirmed the above findings.</p><p><b>CONCLUSION</b>The study indicated that SXE may provide an effective treatment in the prevention of postmenopausal symptoms.</p>

Antimicrobial and antioxidant activities of bauhinia racemosa lam. and chemical content

Methanol 70% extract of Bauhinia racemosa aerial parts was tested for antimicrobial activity against different bacterial and fungal strains and for antioxidant activity and also total content of polyphenols with phytochemical analysis of the extract was determined. The results have showed that the extract has a significant antimicrobial activity, it inhibited the growth of Bacillus subtilis and also it was highly active against Candida albicans suggesting that it can be used in the treatment of fungal infections. The extract has a good antioxidant activity, it has shown high values of the trolox equivalent antioxidant capacity and polyphenol content while it has shown a lower value of oxygen radical absorbance capacity. Phytochemical analysis has shown that it has interesting phytochemical bioconstituents, include flavonoids, tannins and others, and the deep phytochemical study results in the isolation of methyl gallate, gallic, kaempferol, quercetin, querection-3-O-alpha-rhamnoside, kaempferol-3-O-beta-glucoside, myricetin-3-O-beta-glucoside, querection-3-O-rutinoside [Rutin]. All compounds were identified by different spectroscopic analyses [UV, [1]H-NMR, [13]C-NMR] and Mass Spectrometry [MS]

Effect of aqueous extract of Solanum xanthocarpum Schrad. & Wendl. on postmenopausal syndrome in ovariectomized rats / 中西医结合学报

Solanum xanthocarpum Schrad. & Wendl. (Solanaceae) is present in many Ayurveda compound formulations including Chavanaprasha and Dasamoolarishta. The whole plant is used in conditions such as inflammation, constipation and promoting conception in females. In the present study, we carried out different tests to evaluate the effect of aqueous extract of Solanum xanthocarpum (SXE) in postmenopausal syndrome.