Prenatal diagnosis and assessment of fetal malformations by three dimensional ultrasonography at Galaa Teaching Hospital in Egypt

The aim of this study was to determine the effectiveness of fetal anomaly scanning by three dimensional ultrasonography [3 DU/S] in population at risk of fetal anomalies and to confirm the prevalence of anomalies postnatally or by postmortem examination. The sample included 1000 pregnant women at high risk pregnancy of fetal ariomalies examined between [2000-2001]. 1] A detailed 3DU/S examination was performed in each pregnancy between 11-22 weeks of gesetation. 2] Neonatal evaluation or pathological examination was made to confirm the prenatal findings. The total prevalence of fetal abnormalities in our sample was 4.9%. The overall sensitivity in detecting fetuses with congenital abnormalities was 81.6%. The sensitivity per system was 100% for Central Nervous System [C.N.S], 75% for genetic syndromes and 50% for Cardiovascular System [C.V.S.] and Down Syndrome. Some anomalies like hypospadias were not detected prenataly by sonographic examination. In 12 cases pregnancy was terminated due to lethal congenital anomalies [anencephaly and bilateral renal agenesis]. The results indicate that the majority of fetal anomalies can be diagnosed by 3DU/S examination at 11-22 weeks of gesetation. This will be of particular advantage to those women who are at high risk of having affected offspring

use of three dimension ultrasound and colour doppler in assessment of fetal lung and detection of other congenital anomalies in familial diabetic pregnant women

Diabetics Mellitus complications approximalety 3-4 per 1000 pregnancies. It is a syndrome in which hereditasry and environmental factors intersect leading to inadequate insulin action. In this stud we assess fetal lung in family diabetic pregnant women through studding fetal lung circulation by means of pulmonary Doppler investigation, determining fetal lung volume and detection of other malformation if present by using 3D U/S. This study included 60 pregnant women [in the second half of pregnancy] who attended the high risk pregnancy clinic at El Galaa Teaching Hospital. They were classified into two group, group I [control] 20 cases and group II [test group] 40 cases subdivided group II A 20 cases with controlled diabetes and group II B 20 cases with uncontrolled diabetes. All were subjected to color Doppler investigation, 3D U/S and genetic pedigree analysis to select familiar diabetic and interpretation of the results as regards pulmonary circulation, lung volume, birth weight and outcome of pregnancy showed that Diabetes Mellitus wither controlled or not does not significantly alter the fetal pulmonary artery waveforms or fetal lung volume assessed by 3D U/S at does not affect either the fetal lung vasculature or fetal lung mass. However further studies are needed to assess the role of these recent diagnostic tools in evaluating fetal lung maturity

Prenatal Diagnosis and assessment of fetal malformations by three dimensional ultrasonography at Galaa teaching hospital in Egypt

This study included 1000 pregnant women at high risk pregnancy of fetal anomalies. A detailed three-dimensional ultrasonography [3-DUS] examination was performed in each pregnancy between 11-22 weeks of gestation. A neonatal evaluation or pathological examination was made to confirm the prenatal findings. The results showed that the total prevalence of fetal abnormalities in the sample was 4.9%. The overall sensitivity in detecting fetuses with congenital abnormalities was 81.6%. The sensitivity per system was 100% for central nervous system [CNS], 75% for genetic syndromes and 50% for cardiovascular system [CVS] and Down syndrome. Some anomalies like hypospadias were not detected prenatally by sonographic examination. In 12 cases, pregnancy was terminated due to lethal congenital anomalies [anencephaly and bilateral renal agenesis]