ABSTRACT
Background: Young women have low risk of acute coronary syndrome (ACS) during their reproductive period, mainly due to the physiologically protective effect of estrogen hormone on the coronary endothelium. The purpose of this study was to assess the risk factors of ACS in the Egyptian women patients during their reproductive age period, who admitted to Tanta University Cardiovascular department hospital. Results: Obesity, hypertension, diabetes mellitus, chronic kidney disease, systemic lupus erythematosus, myocardial bridge, cushion syndrome and radiotherapy for breast cancer were significantly independently ACS risk factors that correlated to the SYNTAX score. There is significance of coefficient of the independent variable in the risk factors (Group A, group B, group C separately and groups A, B, C together) on the severity and level of SYNTAX score in ACS. The regression analysis was significant in groups A and B of ACS risk factors separately. While the regression analysis was significant and there was a clear relationship between ACS risk factors- groups A, B, C. together and SYNTAX score. Conclusions: There was a positive relationship between the increase total number of ACS risk factors subgroups (Traditional, Nontraditional and Gynecological) and the severity of coronary artery stenosis that assessed by SYNTAX scorer.
ABSTRACT
Background: ST-Elevation myocardial infarction is a major public health problem and a leading cause of death both in developed and developing countries. The values of hematological biomarkers were evaluated as predictors of in hospital mortality and complications, in patients with acute coronary syndromes (ACS). This study aimed to draw a relationship between different hematological parameters and short-term clinical result in STEMI cases treated by primary percutaneous coronary intervention. Methods: This prospective research involved 100 participants that had a STEMI and were receiving primary PCI and they were subjected to detailed history, general and local examination, resting surface ECG, baseline laboratory tests, reperfusion, transthoracic echocardiogram and follow up of clinical outcome. Results: After STEMI, there was not significantly different between cases with low and high NLR (P <0.4). There was significantly different between cases with low and high NLR after STEMI, low and high MPV [in heart failure, death and rehospitalization] and after STEMI, in diabetic patients and in NLR between low and high MPV groups after STEMI (P < 0.05), there was no significant statistical difference between patients with low and high PDW and after STEMI. LVEF were significant less in participants had MACE (P <0.036). In stepwise multivariate regression analysis of hematological parameters, NLR and MPV were significant predictive factors of MACE (P < 0.05). Conclusions: Hematological and coagulation parameters may be utilized as diagnostic and prognostic indicators. Early risk classification enables doctors to closely monitor and treat high-risk patients, as well as schedule them for regular follow-ups, helping to the reduction of mortality.