ABSTRACT
Objectives: Aim was to evaluate clinicopathological and treatment outcomes of diffuse sclerosing variant papillary thyroid carcinoma [DSV-PTC]. Design: Retrospective study. Setting: Two major tertiary care hospitals of Riyadh, Saudi Arabia
Material: Medical records of 1192 patients with confirmed papillary thyroid cancers [PTC], who were treated or followed up during the period of July 2000 and December 2012 were reviewed. Main outcome measure: To evaluate the clinicopathologic features and treatment outcomes of patients with DSV- PTC and perform comparative analysis of DSV-PTC with classic-variant PTC [CV-PTC]
Results: A total of 44 cases [3.7%] of DSV-PTC were identified. DSV-PTC patients were younger than their CV-PTC [p = 0.001]. The mean tumor size was larger in DSV-PTC as compared to CV-PTC [p < 0.0001]. Advanced pathologic tumor [pT] stage and positive lymph nodes were more often present in DSV-PTC than in CV-PTC [p < 0.0001 and p < 0.0001 respectively]. Median follow-up was 8.05 years [range: 1.62-11.4]. Ten-year disease-specific survival [DSS] rates were lower in DSV-PTC [74.4%] than in CV-PTC [89.4%]; p = 0.001
Conclusion: DSV-PTC is more aggressive variant as compared to CV-PTC, and is associated with inferior DSS rates. An aggressive surgical approach followed by radioiodine therapy is warranted for these patients
ABSTRACT
A Thyroglossal duct cyst [TGDC] is the most frequent congenital cervical anomaly [70% in children and 7% in adults] in the development of the thyroid gland. However, incidence of carcinoma arising from a TGDC is extremely rare [=1%] and is diagnosed during the pathologic examination of thyroidectomy specimen. To date, only fewer related cases have been reported to the literature. Among those cases, only few were diagnosed as primary TGDC papillary carcinoma. Here in, we present a case of 25 year old woman with primary TGDC papillary carcinoma identified after sistrunk surgery. Later on, patient underwent total thyroidectomy, bilateral neck dissection and adjuvant radioactive iodine ablation. The patient was alive and without any recurrence at fifth year of follow-up after her initial diagnosis.