ABSTRACT
Recurrent pleural effusions are relatively uncommon and as clinicians we keep drug induced pleural effusion lower in our list of differentials. Pramipexole induced recurrent pleural effusion can be life threatening if not recognized early and has been reported in literature only a few times. A 44 years old man with history of traumatic brain injury presented with pneumonitis and p leural effusion which was tapped. Patient returned with pleural effusion within 2 weeks and a careful analysis of all the risk factor and drugs revealed that the most likely etiology was chronic use of Pramipexole leading to recurrent pleural effusion and early pulmonary fibrosis. Pramipexole induced recurrent pleural effusion can cause significant morbidity and should be recognized early. Physician prescribing this medication should be aware of this rare side effect of the medication