ABSTRACT
To determine the significance of alanine aminotransferase [ALT] level in tfirbftib hepatitis C infection in our setup. A prospective cross-sectional, observational study carried out from August 2006 to June 2008. Departments of Pathology, Nawabshah Medical College Nawabshah and research institute of LUMHS Jamshoro. A total of 344 HCV-PCR positive patients having histological evidence of chronic hepatitis with either fibrosis or inflammatory activity by biopsy were evaluated 239 men and 105 women with ages between 18-55 years of age were included in the study. All the patients went for FLISA test for the presence of HCV antibodies by ELISA kit of Biokit Spain, and then a 5.0 ml of blood was collected in a tube with separating gel, to obtain serum, which was stored at room temperature for the determination of alanine aminotransferase by Ecoline kit on Slectra automatic chemical analyzer of Merck, Germany. The ALT was estimated in 344 patients and was 4.4 times higher [mean level
54.5 U/L] than normal in 335 [97.38%] patients, while 09 [2.61%] patients showed ALT level with in normal limit. The data in the current study indicates importance of ALT in chronic hepatitis C infection, and shows that ALT is the major liver enzyme and is a marker of liver infection or hepatitis, as majority [97.38%] of patient in our study showed a high level of ALT