Proliferative glomerulonephritis with acute renal failure-a rare manifestation in seronegative rheumatoid arthritis.

A 55 years old lady with advanced rheumatoid arthritis (RA) presented with severe acute renal failure with significant proteinuria preceded by fever for 14 days. She had no history of taking drugs usually responsible for glomerulonephritis, neither had she any clinico-biochemical evidence of peri-infectious glomerulonephritis. Acute interstitial nephritis (AIN) was excluded by absence of eosinophilia and eosinophils in urine. Renal biopsy reveled absence of amyloidosis and showed Focal segmental proliferative glomerulonephritis (FSGN). Patient was successfully managed with methyl-prednisolone followed by steroid and immunosuppressive and patient came over renal failure. So FSGN should be considered as one of the causes of acute renal failure in a patient with seronegative RA which may respond to immune-therapy like rapidly progressive glomerulonephritis.

High vaginal swab(HVS), routine microscopy and culture sensitivity in diabetic and non diabetic, a comparative retrospective study of five years.

Diabetic women are significantly more prone to develop vaginitis (both bacterial and fungal) than non diabetic. Among the positive cases predominant bacterial isolate being E. Coli. All fungus positive culture yielded the growth of candida species. Direct wet film preparation of the fungus positive cases revealed only 30% were positive for fungus, thus if candida vaginitis is suspected, the diagnosis cannot be ruled out on the basis of negative direct preparation. More over, diabetics should be advised maintain proper glycaemic control and personal hygiene to get rid of this distressing problem.