ABSTRACT
Background: Chronic lumbar radiculopathy a clinical condition in which there is back and leg pain associated with sensory, reflex, or motor deficits in the area of nerve root distribution lasting for more than 12 weeks. The prevalence of lumbar radiculopathy has been reported to be 5.3% in men and 3.7% in women. Pregabalin and gabapentin, which fit in to a new category of drugs called as alpha-2-delta (?2?) modulators, have been discovered to be effective in the treatment of neuropathic pain related with multiple conditions. So this study was done to compare safety and efficacy of pregabalin and gabapentin in management of pain associated with chronic lumbar radiculopathy.Methods: This was a randomized two arm comparative prospective study. Total 160 patients were enrolled and randomized equally into 2 groups. Group A patients were given capsule pregabalin 75 mg two times a day orally, Group B patients were given tablet gabapentin 300 mg two times a day. Pain intensity was assessed at the start of study i.e. at baseline (0 week), at 6 weeks and at 12 weeks of starting the treatment using numeric pain rating scale.Results: There was significant reduction in pain at the end of 12 weeks in both the groups (p<0.0001), but there was no significant difference between these two groups. The incidence of adverse effects was also more in group A.Conclusions: Both the drugs are having comparable efficacy but gabapentin is more tolerable in such cases.
ABSTRACT
Background: According to WHO Pharmacovigilance is “The science and activities which are related to the detection, assessment, understanding, and the prevention of adverse effects or any other drug-related problems.” A majority of India’s population prefers government hospitals when they are in need of health care facilities. The patients also prefer other available free health care facilities. Hence, these hospitals can be a good source for generating an adverse drug reactions database. However, the Herculean task is to foster a culture of reporting among the doctors, especially among the junior doctors, as they are more closely associated with the patient care, hence the present study to assess awareness of pharmacovigilance among the doctors and to evaluate the impact of an educational intervention for improving awareness of pharmacovigilance among doctors in an Indian tertiary care teaching hospital. Methods: A suitable self-administered knowledge, attitude, practice (KAP) survey questionnaire was designed, based on previous studies. An interventional educational activity was organized and the impact of the educational Intervention was evaluated by again administering the similar questionnaire. The statistical analysis was carried for comparing the pre- and post-intervention. Results: It was seen that the KAP of pharmacovigilance among doctors is low. The results also showed that there was an improvement after the educational intervention. Conclusions: The KAP of pharmacovigilance is low among doctors and educational intervention can improve it.