ABSTRACT
Introduction: Malnutrition is common in patients withEnd Stage Renal Disease (ESRD) on Hemodialysis (HD).Depending on the parameter measured, the prevalence ofmalnutrition in the chronic dialysis population ranges from 10to 54%. It is related with the secretion of a number of proteins(adipokines), including leptin and adiponectin and alsocytokines such as IL-6. This study was planned with the aimof reviewing the association of nutritional status with serumleptin and CRP levels in hemodialysis patients.Material and methods: The present study was conducted inthe department of Medicine at Chattrapati Shivaji SubhartiHospital from August 2017 to March 2019; consisted of50 patients of End stage Renal Disease on maintenancehemodialysis admitted in Chattrapati Shivaji Subharti Hospitalduring the time period.Results: Out of the 50 subjects, 35 (70%) were male and15 (30%) were females. The Lean Body Mass (%) in thestudy subjects was 59.76±5.92. The overall mean leptinlevel distribution among the subjects was 1.51±0.36. Theoverall mean CRP level distribution among the subjects. was3.75±0.47. A positive correlation was found between CRPand BMI with statistical significance as p<0.05 (table 11).Similarly a highly positive correlation was found betweenLeptin and BMI as p<0.01.Conclusion: Our study point to possible use of serum leptinand CRP concentration as an indicator of nutritional status inHD patients based on observed significant positive correlationbetween serum leptin and CRP concentrations with BMIvalues.
ABSTRACT
Introduction: Epidural anaesthesia and analgesia hasjustified use in the perioperative care of high-risk surgicalpatients, as they give better analgesia, and also improvedoutcome. Thoracic Epidural analgesia is an excellent methodof postoperative and post injury pain control in proceduresinvolving significant thoracic and abdominal injury weathertraumatically or surgically induced. Though Bupivacaine isconsidered to be the drug of choice, many other agents arebeing used for epidural anesthesia.Material and Methods: This study was carried out on 105ASA grade I and II nulliparous patients, between 20 to 70 yearsof age undergoing laparotomy, voluntary donor nephrectomyand renal surgeries. They were randomly divided in theBuprenorphine, Bupivacaine and Fentanyl Groups. Quality ofanalgesia and post-operative complications were monitored.Results: Analgesic failure was observed in all the threeGroups. But complete pain relief was better in theBuprenorphine Group. Also, complications (hypotension,bradycardia, sedation) were less in the Buprenorphine Groupthan in the Bupivacaine and Fentanyl Groups.Conclusion: Buprenorphine is safer and provides betterquality analgesia than Bupivacaine and Fentanyl.
ABSTRACT
The current article reviews alcohol consumption and tobacco smoking amongst South Asian Indians in Britain. Inequalities due to income, health economics and social issues amongst different groups of Indians are explored. Articles from PubMed, Medline and WHO databases were sought. ICF criteria were applied for selection of articles: impact factors; rated by relevance; criteria for selection [appropriateness of methodology; adequacy of subject numbers; specificity of sex and/or age of subjects; and statistically significant response rates to survey questionnaires]; time frame of 1990-2007. Out of a total of 122 articles, 112 were accepted and 85 utilised. In 1999, the incidence of drinking more than 21 and 14 units of alcohol per week amongst Indians in Britain was 14% in men and 2% in women, respectively. This was considerably less that equivalent consumption in the general population of 30% and 18%, respectively. In 1999, the incidence of cigarette smoking and the use of tobacco products amongst Indians included 23% of men smoking cigarettes and 5% using tobacco products, and 6% of women smoking cigarettes and 2% tobacco products. The overall prevalence of tobacco use was 32% amongst men and 27% amongst women in the general population, respectively. Studies of populations of South Asian Indians from lower social groups with larger numbers of samples resident in Britain should help to confirm associations between health and alcohol and/or tobacco smoking. Research is required to identify the exact causal factors amongst South Asian Indians in particular Indians that result in the increase [mis]use of alcohol and tobacco smoking