ABSTRACT
Background: Inhalers containing corticosteroid and a long acting ?2 agonist (LABA) are widely used in asthma treatment. This study assessed the patient sensory perception and satisfaction of budesonide/formoterol fixed dose combination by pressurized metered dose inhalers (pMDI) with spacer and dry powder inhalers (DPI) in patients of moderate persistent asthma.Methods: This was a 6 week prospective, randomized, open label, comparative, parallel group clinical study. All patients had a forced expiratory volume in 1 second (FEV1) of 60-80% predicted normal. The patients were assessed for sensory perception and satisfaction in group I (pMDIs with spacers) and group II (DPIs) using patient evaluation questionnaire (PEQ) and patient satisfaction and preference questionnaire (PASAPQ) at the end of 6th week.Results: In PEQ, statistical analysis of the mean attribute ratings showed that both the devices were easy to use by patients. More medication was felt reaching throat using DPIs. Patients on DPI liked the taste and felt it to be less strong than patients on pMDIs. The overall liking was statistically comparable in two groups. In PASAPQ, the patients on DPI group were very satisfied with the treatment than pMDI (p<0.05).Conclusion: Overall liking of both DPIs and pMDIs was comparable and patients on DPI were satisfied more with the treatment device. Patient sensory perception and satisfaction may be taken into account in selecting device to improve compliance to treatment.
ABSTRACT
The present study was undertaken to compare the effects of Melatonin 3 mg, Pregabalin 75 mg andAlprozolam 0.5 mg as premedicant drugs for reduction in perioperative anxiety and post operative pain,assessment of level of sedation. 150 patients of ASA grade I and II, between 20 - 50 years, of eithersex, undergoing laparoscopic surgery were divided into 3 groups of 50 patients each. Baseline anxietylevel and level after 1hr of drug was assessed. Also postoperative anxiety at different intervals wasassessed. Similarly postoperative pain and level of sedation at different intervals was assessed. Patients in group M were highly sedated as compared to group P and group A at all intervals and thedifference was statistically significant. All the three groups were comparable regarding postoperativepain, perioperative anxiety and side effects at all intervals and the difference was statistically insignificant at all intervals.
ABSTRACT
Ovulatory dysfunction is one of the leading causes of female infertility. Clomiphene citrate has emerged as a boon in the induction of ovulation in the human female. Clomiphene results in many adverse effects some of which are documented, and some reported spontaneously. Clomiphene citrate is a non-racemic mixture of two isomers, zuclomiphene and enclomiphene, having individual and opposite biological actions. It is accepted that cis isomer (zuclomiphene) is estrogenic and trans isomer (enclomiphene) is anti-estrogenic. Zuclomiphene does not have any ovulation-induction propertybut gets accumulated for a longer time in the human body and it has more agonistic activity than enclomiphene. Thus, Zuclomiphene may be responsible for the adverse effects by clomiphene citrate. Enclomiphene is being explored for its potential use in male as well as female infertility. Trails are underway to explore its effectiveness and safety in various disorders. This article highlights the pharmacology of Clomiphene with respect to its isomers and the potential uses of enclomiphene based on evidences available.
ABSTRACT
The present study was undertaken to compare the efficacy of Lignocaine 0.5% with Ropivacaine 0.2 & 0.25% in IVRA. 90 patients of ASA grade I & II, between 20 to 50 years of either sex undergoing forearm surgery lasting less than 1 hour were taken and divided into 3 groups of 30 patients in each group. Double pneumatic tourniquet was placed on affected arm and arm was elevated for 2 minutes and exanguinated with esmarch bandage. Proximal cuff was inflated 100mlHg above the systolic pressure and the drug was given. After 10 minutes, distal cuff was inflated and proximal cuff was deflated. There was a highly significant difference between onset of sensory and motor block in Group I & II, Group I & Group III. Sensory and motor recovery time had highly significant difference between Group I & II, Group I & III. There was a highly significant difference regarding duration of analgesia among the three groups with Group I with least duration and Group III with maximum duration of analgesia. In our study Ropivacaine with two different concentrations 0.2% and 0.25% provided good quality of intra-operative analgesia, delayed motor and sensory blockade and prolonged duration of analgesia as compared to lignocaine 0.5%.