ABSTRACT
This case highlights the importance of histopathological examination in all cases of choristoma undergoing excision.
ABSTRACT
Background: Neuroblastoma (NB) is the fourth most common tumor of childhood. There is a paucity of literature on its subtyping of cytology and prognostic utility. Aims: We aimed to study the cytopathological features of NB on the aspirated material, subtype it, and assess the role of International Neuroblastoma Pathology Classification (INPC) classification on cytology smears in the preoperative prognosis of NB. Materials and Methods: Fifteen cases of NB reported on fine-needle aspiration cytology (FNAC) in the past 3 years were included. Detailed clinical, radiological, and cytological features were noted. Smears were assessed for characteristics such as cellularity, neuroblasts (cytoplasmic, nuclear details), rosettes, neuropil, Schwann cells, fibroblasts, calcification, and necrosis. Afterward, cases were categorized as undifferentiated (UD), poorly differentiated (PD), and differentiating (D) subtypes. Mitotic-karyorrhectic index (MKI) was calculated and correlated with histopathology. Follow-up was done to date. Results: The age ranged from 19 days to 10 years with an M: F ratio of 3:1. Twelve cases were retroperitoneal, two cervical, and one mediastinal. Metastatic disease was seen in six cases, one to the cervical, four to the bone marrow, and two to the scalp. The International Neuroblastoma Risk Group (INRG) staging system was available in all cases, out of which three were in stage L1, six in stage L2, four in stage M, and two in stage Ms. On cytology, four cases were differentiating NB, five PD NB, and six UD NB. The MKI was high (>4%) in 80% of UD, intermediate (2–4%) in 100% of PD, and low (<2%) in 75% of D cases. MKI corroborated in both histology and cytology, except in one case. Conclusion: NB can be subtyped on cytology on the basis of characteristics of neuroblasts, presence of neutrophils, rosettes, and necrosis. UD NB has a high MKI and is associated with a poor prognosis. A preoperative comprehensive reporting of NB on cytology can be very useful in guiding appropriate chemotherapy with some increment in survival. However, larger studies are needed to validate the calculation of MKI on FNA smears.
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Background: The physical discomfort and collection of symptoms after digital screen use for longer than two hours at a time is referred by the Vision Council as digital eye strain (DES). Common symptoms of DES are eyestrain, headache, blurred vision, dry eyes and pain in neck and shoulders. This study aims to know about the prevalence; factors associated with and awareness about preventive measures for DES among college students.Methods: A cross-sectional study was conducted for 2 months in 2017 among randomly selected 200 college students of 20 to 30 years of age in Indore city of Madhya Pradesh using a pre-designed semi-structured questionnaire.Results: Mean age of participants was 22.5 years; of which 58% were females. Of the respondents, 89.5% (179 students) reported experiencing DES. Average distance from digital screen, brightness level of digital device, use of digital device before going to sleep and awareness about appropriate distance of digital screen from eyes had statistically significant association with having digital eye strain. 98% of respondents were unaware of the term DES while >60% did not have knowledge about the harmful blue light emitted by digital devices, protective use of digital screen filters, appropriate distance of viewing digital screen and the 20-20-20 rule of taking breaks in between screen time.Conclusions: Since digital device use is a necessary evil; better ergonomic practices to avoid DES should be adopted. Opportunistic health promotion and patient education undertaken by ophthalmologists on an OPD basis is one solution.
ABSTRACT
To evaluate and compare the shear bond strength of conventional composite resin and nanocomposite resin to sandblasted primary anterior stainless steel crown. The study samples consisted of 30 primary anterior stainless steel crowns (Unitek TM, size R4), embedded in resin blocks with crown, in test groups of 15 samples each. Mounting of the crown was done using resin block with one crown each. Sandblasting was done and the bonding agent Prime and Bond NT (Dentsply) was applied on the labial surface of the primary anterior sandblasted crown. The composite resin and nanocomposite resin were placed into the well of Teflon jig and bonded to Stainless Steel Crowns. The cured samples were placed in distilled water and stored in incubator at 37 degrees C for 48 hours. Shear bond strength was measured using universal testing machine (Hounsefield U.K. Model, with a capacity of 50 KN). Independent sample 't' test revealed a nonsignificant (P < 0.385) difference between mean shear bond strength values of conventional and nanocomposite group. The bond strength values revealed that nanocomposite had slightly higher mean shear bond strength (21.04 +/- 0.56) compared to conventional composite (20.78 +/- 0.60). It was found that conventional composite resin and nanocomposite resin had statistically similar mean shear bond strength, with nanocomposite having little more strength compared to conventional composite.