ABSTRACT
Background: Chronic alcohol consumption gives rise to various health risks that include liver disease, heart disease, pancreatitis, central nervous system disorders and certain forms of cancer. Alcoholic liver disease (ALD) is a spectrum of clinicopathological abnormalities, reflecting an acute or chronic inflammation of the liver parenchyma induced by alcohol use. It is associated with changes in various biochemical parameters and also various clinical manifestations in the patients. The objective of the present study to evaluate clinical and biochemical profile of acute alcoholic liver disease.Methods: The prospective hospital-based case control study was done at MNR Medical College, in the department of General Medicine for duration of one year from March 2017 to April 2018. A total of 120 cases diagnosed clinically and biochemically as Acute alcoholic liver disease were included in the study.Results: The age group ranged from 20 to 60 years and the male to female ratio was 2.42. Majority of the patients were in the age group of 30-40 years (54.1%). Majority of the patients (66.6%) consumed >60 grams/24hours of alcohol. Jaundice, nausea and vomiting were seen in 83.3% cases followed by hepatomegaly in 66.6% cases. Majority of them had been consuming alcohol for more than 5 years.Conclusions: Chronic alcohol consumption is more common in adult males. Chronic alcoholics consume more amount of alcohol. Alcoholic liver disease has a varied clinical presentation and is associated with deranged biochemical parameters.
ABSTRACT
Introduction: Dengue is one of the most important viral diseases especially in the tropical regions. This disease increases in incidence in the immediate post monsoon period coinciding with the breeding of mosquitos in the stagnant water. It has varied clinical presentation and more or less consistent abnormal laboratory values on complete blood count test. Aim of the study: The aim of the study was to determine the clinical and hematological profile in patients with Dengue fever. Materials and methods: This was a prospective study done in the department of General Medicine at Dr. Pinnamaneni Siddhartha Institute of Medical sciences and Research Foundation, Andhra Pradesh, over duration of 7 months. The study included 60 patients admitted in the hospital and all the cases were IgM dengue positive. Results: There were 40 (66.6%) male and 20 (33.3%) female patients. Out of 60 patients, 30 (50%) were in age group of 20 to 30 years. Most of the cases were found in post monsoon period in September and October. In our study out of 60 cases of dengue fever, raised hematocrit (>47%) was noted in 10 (16.6%) of patients at presentation and 50 (83.3 %) cases had thrombocytopenia, in which 8 (13.3%) cases had < 20,000/cumm with bleeding manifestations. Conclusion: Most common clinical presentation of Dengue fever is of fever with or without myalgia and presence of hepatosplenomegaly. Young adult males are more commonly affected. The most common laboratory abnormalities are of an increase in hematocrit, low total leucocyte count and low platelet count.