ABSTRACT
To determine the histological aspects and associated factors to significant or severe fibrosis in patients with chronic viral hepatitis C. Consecutive patients recruited between 1999 and 2005 were studied. Lecture of hepatic biopsies was performed by the same histopathologist, using the METAVIR grading. We investigated 109 patients [36 men and 73 women, mean age:49.3 years [19 - 65 years]. Activity was graded AO, Al, A2 and A3 in respectively 2,49,51 and 7 cases. Fibrosis was graded FO, Fl, F2, F3 and F4 in 3, 34, 35, 16 and 21 cases. In univariate analysis, associated factors to fibrosis more than F2 were age, diabetes, levels of AS AT, gamma glutamyl transpeptidase, alkaline phosphatase, prothrombin index and APRI score. In multivariate analysis, only age more than 50 years was associated with fibrosis more than F2 [p=0,006 adjusted OR [CI95%] :5,57[1,63 - 18,9]]. Associated factors to fibrosis graded F4 were age, levels of AS AT, ALAT, gamma glutamyl transpeptidase, alkaline phosphatase, leucocytes, platelets, prothrombin index, APRI score and hepatic dysmorphy on ultrasound examination. In multivariate analysis, only APRI score more than 1,5 was associated with fibrosis graded F4 [p=0,04 adjusted OR[CI95%] :4,35[2,25-6,76]]. Age and APRI score are important prognosis factors in chronic viral hepatitis C
ABSTRACT
Background: Mixed mullerian tumours are uncommon endometrial neoplasms that are composed by a combination fo mesencymal elements and epithelial elements. They own their denomination to the mullerian origin of their components wich derive from the paramesonephric ducts
According to the benignity of the malignity of each component, four types of mixed mullerian tumours are individualised. Adenosarcoma is composed of benign glandular elements and sarcomatous, usually low-grade, stromal elements
Aim: We report a case of an endometrial adenosarcoma in a 59-year-old-woman
Clinicopathological caracteristics and the etiopathogeny of this uncommon neoplasm will be discussed
Case: A 59 year old women complained metorrhagia assearated pair since three months. Vaginal examination showed an incresed valure. Copathological U.S and abdominer CT showed an important. No ather tumer were detected hysterrchomy with dilated annexctny were performed. Pathological examan concluded to tummor with animation of mesenchynal and lepthel elements