ABSTRACT
No abstract available.
ABSTRACT
Colorectal polyps of mesenchymal origin are a rare group of colorectal disorders. A "mucosal Schwann-cell hamartoma," which is one type of polypoid lesion that originates from the mesenchyme, is a newly-proposed disease entity to be distinguished from the neurofibromas found in type-1 neurofibromatosis. This lesion is composed of pure Schwann-cell proliferation in the lamina propria and shows diffuse immunoreactivity for the S-100 protein. We report a case of a polypoid lesion of the colon with the features of this recently-proposed disease entity.
Subject(s)
Colon , Hamartoma , Mesoderm , Mucous Membrane , Neurofibroma , Neurofibromatoses , Neuroma , Polyps , S100 Proteins , Schwann Cells , SNARE ProteinsABSTRACT
A 39-year-old woman was admitted to our hospital because of her chronic cough. She had undergone modified radical mastectomy for breast cancer 7 year before admission. A chest radiograph showed collapse of the left upper lobe (LUL) and computed tomography of the chest revealed a mass in the proximal portion of the LUL bronchus and distal atelectasis. Bronchoscopy showed obstruction of the LUL bronchus. The microscopic examination showed findings consistent with breast cancer with the same immunohistochemical features for the hormone receptors, as compared to those features of the previously resected tumor. Positron emission tomography showed increased fluorodeoxyglucose uptake only in the LUL. Left upper lobectomy was performed and she is now undergoing systemic chemotherapy. We report here on this rare case to emphasize that when a patient with a history of breast cancer complains of respiratory symptoms, and even though the patient was treated curatively a long time ago, we should suspect the possibility of endobronchial metastasis.
Subject(s)
Adult , Female , Humans , Breast , Breast Neoplasms , Bronchi , Bronchoscopy , Cough , Lung Neoplasms , Mastectomy, Modified Radical , Neoplasm Metastasis , Positron-Emission Tomography , Pulmonary Atelectasis , ThoraxABSTRACT
Mantle cell lymphoma (MCL) is a recently redefined category of malignant lymphoma that has been indivisualized under different names, because of classifications, such as the Working Formulation, fail to recognize it. In the Working Formulation, MCL is classified as diffuse small cleaved cell lymphoma most frequently. Immunophenotyping has a tremendous value in diagnosis of MCL and adds the accuracy of diagnosis. It more commonly arises in peripheral lymph nodes, but in colon, usually presents as a diffuse infiltration, known as multiple lymphomatous polyposis and lymphomatous polyposis can be regarded as the intestinal form of MCL. We recently experienced a case of recurrent MCL presented with a peculiar feature of intestinal lymphomatous polyposis in a 57-year old male patient. He had been diagnosed diffuse small cleaved cell lymphoma of tonsil and treated by CHOP chemotherapy. He developed a recurrence in stomach, colon, liver, spleen and bone marrow after 16 months in complete remission. We could confirm the previously diagnosed lymphoma of tonsil as MCL by adding immunophenotyping with cyclin D1 and CD5. He received salvage chemotherapy and responded partially. We report a case of MCL relapse in the form of intestinal lymphomatous polyposis and literatures are reviewed.