ABSTRACT
Background: Anaemia is very common in developing countries especially during pregnancy. Hyperhomocysteinaemia can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathway for homocysteine metabolism. Inadequate intake of vitamin B ,B or folate may underlie some cases of elevated homocysteine levels. The aim of this 12 6 study was to investigate the possible relationship between plasma homocysteine level, haemoglobin level and 24-hour urinary protein in pre-eclamptic patients. Folic acid deficiency is one of the major causes of hyperhomocysteinemia which is one of the major risk factor for preeclampsia [PET]. Severe proteinuria of several grams/day occurs in pre-eclamptic toxaemia
Methods: A cross-sectional comparative study was carried out on 90 primigravida attending the "antenatal clinic" of Services Hospital, Lahore
Results: Out of these 60 primigravida 30 were mildly preeclamptic and 30 were severely pre-eclamptic at 30-38 weeks of pregnancy.30 primigravida [30- 38 weeks of pregnancy] having uncomplicated pregnancy were taken as control
Conclusion: The results show that in mild PET and in severe PET, the plasma homocysteine level shows a significant relationship with 24-hour urinary protein and haemoglobin level. Anaemia [folic acid defeciency] is one of the important risk factor in the causation of hyperhomocysteinemia which is one of the major chronic risk factors for eclampsia
ABSTRACT
Background: Anaemia is very common in developing countries especially during pregnancy. Hyperhomocysteinaemia can result from genetic or nutrient-related disturbances in the transsulfuration or remethylation pathway for homocysteine metabolism. Inadequate intake of vitamin 8[12],B[6] or folate may underlie some cases of elevated homocysteine levels. The aim of this study was to investigate the possible relationship between plasma homocysteine level, haemoglobin level and 24-hour urinary protein in pre-eclamptic patients. Folic acid deficiency is one of the major causes of hyperhomocysteinemia which is one of the major risk factor for preeclampsia [PET]. Severe proteinuria of several grams/day occurs in pre-eclamptic toxaemia
Methods: A cross-sectional comparative study was carried out on 90 primigravida attending the "antenatal clinic" of Services Hospital, Lahore. Out of these 60 primigravida 30 were mildly preeclamptic and 30 were severely pre-eclamptic at 30-38 weeks of pregnancy. 30 primigravida [30-38 weeks of pregnancy] having uncomplicated pregnancy were taken as control
Results: The results show that in mild PET and in severe PET, the plasma homocysteine level shows a significant relationship with 24-hour urinary protein and haemoglobin level
Conclusion: Anaemia [folic acid deficiency] is one of the important risk factor in the causation of hyperhomocysteinemia which is one of the major chronic risk factors for eclampsia