The antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice

Background: Schizophrenia is one of the most distressing central nervous system (CNS) disorders. It is described by positive, negative and cognitive symptoms. These symptoms can be controlled by the antipsychotic medicines. The numerous antipsychotic medications used today are not lacking the adverse drug reactions. The Withania coagulans a susceptible species, is not explored much for its CNS effects except in late seventies. Therefore, it was thought worthwhile to investigate anti-psychotic activities of alcoholic extract of Withania coagulans fruits. The objective of the present study was to assess the antipsychotic activity of alcoholic extract of Withania coagulans fruits in Swiss albino mice by Cook’s Pole Climb Apparatus for conditioned avoidance response (CAR)Methods: Cook’s Pole Climb Apparatus for conditioned avoidance response was used for assessing the antipsychotic activity of the alcoholic extract of 200mg/kg, 500mg/kg and 1000mg/kg doses of Withania coagulans fruits.Results: There was statistically (p-value >0.05) no significant association between any of the 200mg/kg, 500mg/kg and 1000mg/kg doses of the alcoholic extracts of Withania coagulans fruits with antipsychotic activity in Swiss albino mice.Conclusions: Withania coagulans fruits alcoholic extract did not demonstrate antipsychotic activity in Swiss albino mice under standard conditions.

Systematic review of adverse drug reactions of ofloxacin

Adverse drug reactions (ADRs) are a major cause of morbidity and mortality in countries having limited healthcare resources. Of all the Adverse Drug Reactions, antimicrobials contribute 28% which is highest compared to the other drugs. Ofloxacin is an antimicrobial used for treating several bacterial infections. Incidence rate of adverse drug reactions (ADRs) to ofloxacin is 4.27%. Although these figures appear to be small, it is consumed for gastrointestinal infections along with ornidazole in India contributing significant burden of ADRs. However, there is no research done in past many years focusing on the adverse drug reactions of ofloxacin. This article bridges the gap of such a need. The objective of the present study was to review the adverse drug reactions related to ofloxacin in human and animal studies. Authors conducted Pubmed and Cochrane library search to review all the articles related to the adverse drug reaction of ofloxacin from 1980 to 2016. Authors got 84 articles pertaining to the adverse drug reactions of ofloxacin. Authors conclude that ofloxacin should be judiciously used as the side effect profile is increasing.