ABSTRACT
This study was aimed to evaluate and to compare the acute and subchronic toxicities of the hydroethanolic extracts of theroot (HECRB) and stem bark (HECSB) of Cassia sieberiana in rats. In acute toxicity study, animals were divided into 2groups (n = 3). Rats received the single dose of 5000 mg/kg of HECRB and HECSB extracts of C. sieberiana orally. Forthe subchronic toxicity, 4 groups (n = 6) were given daily 500 and 1000 mg/kg of extracts for 28 days. Animal behaviorswere observed after each treatment. Results showed that HECRB and HECSB were not toxic at 5000 mg/kg. The LD50was >5000mg/kg for both extracts. After repeated doses of 500 and 1000 mg/kg, both extracts did not significantly affectthe relative organs weight of treated rats. HECSB did not affect biochemical and hematological parameters. However,HECRB significantly increased parameters such as red and white blood cells, hemoglobin, volume globulaire moyen,teneur corpusculaire moyenne en hemoglobine, and triglycerides. This study showed that HECRB and HECSB are nottoxic. It contributes to a better knowledge of the toxicity of C. sieberiana used for the treatment of several diseases in Togo.
ABSTRACT
This present study was performed to evaluate the hepatoprotective effect of Aframomum melegueta seeds, used as spicy in the traditional conditions. The hepatoprotective activity of the seeds of A. melegueta at 100 and 150 mgEq.pp/kg, administered orally, was assessed using carbon tetrachloride-induced (CCl4) liver damage (1 ml/kg bw 1:1 CCl4 and corn oil). The results obtained from this study show that A. melegueta produced a significant decrease in serum transaminases and alkaline phosphatase. At the dose of 150 mg Eq.pp/kg, A. melegueta induced a significant increase in serum total proteins. Liver and serum antioxidant potentials were also significantly increased. Those results indicate that A. melegueta seeds protect the liver against toxicity induced in this study.