ABSTRACT
Backgrounds and Objectives: Very few analytical studies are available on any association between Colorectal Cancer [CRC] among diabetic patients compared with non-diabetic subjects at least in Iran. The aim of this case control study was to determine the risk of CRC in type 2 diabetic patients
Materials and Methods: In this study, 207 CRC cases, who had positive results by colonoscopy and biopsy, from Colonoscopy units in Tabriz Referral hospitals and 207 controls, gender and age matched had negative colonoscopy and biopsy results, was selected from the same centers with no history of any malignant tumor and nonneoplastic, Data were collected by questionnaires, and entered into the SPSS19. Multivariate logistic regression was used to estimate odds ratios adjusting for diabetes and risk of CRC
Results: of 414 patients studied, 194 [47%] females and 220 [53%] patients were men. The mean age and Body Mass Index [BMI] of patients was respectively, 59.52 +/- 13.8 and 26.47 +/- 3.8 Kg/m2. Of 207 patients with colorectal cancer, 48 patients were diagnosed with diabetes in contrast of 207 controls only 21 patients were diagnosed with diabetes. The final analyses indicate that diabetes increase the risk of CRC. [OR: 2.57, %95 CI: 1.25-4.58, P=0.006]
Conclusions: Our findings indicate that Diabetes increase the risk of CRC