1.
Indian J Exp Biol
;
1987 Mar; 25(3): 190-3
Article
in English
| IMSEAR
| ID: sea-62596
2.
Indian J Physiol Pharmacol
;
1987 Jan-Mar; 31(1): 19-24
Article
in English
| IMSEAR
| ID: sea-108560
ABSTRACT
Dichlorvos (O, O-dimethyl O-(2,2-dichlorovinyl phosphate: DDVP 76.6 X EC) an organophosphate pesticide had a profound effect on cardiac activity of albino rats. Adult male rats anesthetized with pentobarbitone were administered 30, 50, 70 and 90 mg/kg body weight of dichlorvos. The heart rate and electrocardiogram were monitored and acetylcholinesterase activity was measured in heart and brain. Dichlorvos produced abnormalities in ECG, decrease in heart rate, cardiac arrest and inhibition of cholinesterase activity. It is suggested that cardiotoxic effect of DDVP may be mediated by the accumulated acetylcholine as a result of cholinesterase inhibition.
Subject(s)
Animals , Cholinesterase Inhibitors , Dichlorvos/toxicity , Electrocardiography , Female , Heart/drug effects , Heart Arrest/chemically induced , Heart Rate/drug effects , Lethal Dose 50 , Male , Rats , Rats, Inbred Strains
3.
Indian J Exp Biol
;
1981 Dec; 19(12): 1163-8
Article
in English
| IMSEAR
| ID: sea-55664
Subject(s)
Animals , Hexachlorocyclohexane/pharmacology , Liver/drug effects , Mice , Organ Size/drug effects , Rats
4.
Indian J Exp Biol
;
1980 Oct; 18(10): 1148-51
Article
in English
| IMSEAR
| ID: sea-60904
Subject(s)
Animals , Female , Hydrocarbons/toxicity , Kidney/pathology , Lethal Dose 50 , Liver/pathology , Pesticides/toxicity , Rats , Xylenes/toxicity
5.
Indian J Exp Biol
;
1980 Aug; 18(8): 854-7
Article
in English
| IMSEAR
| ID: sea-57928