ABSTRACT
Objective To investigate the clinical features and treatment of vaginal intraepithelial neoplasia (VAIN).Methods Clinical data of 50 patients with VAIN,aged 33-76 years,were retrospectively analyzed.Among them,16 patients were diagnosed with grade Ⅰ VAIN,5 with grade Ⅱ VAIN and 29 with grade Ⅲ VAIN.Results A majority of VAIN patients presented with no clinical symptoms,whereas few cases were manifested with increased vaginal secretion.The lesions were located in the vaginal fornix or the upper 1/3 of the vagina in 82％ of patients,and in the middle and lower 1/3 of the vagina in the remaining 18％ cases.Patients with VAIN Ⅰ were observed during follow-up,VAIN Ⅱ patients were given with local administration of medication,and VAIN Ⅲ patients received three-dimensional high-dose rate after loading intracavitary radiotherapy.Human papilloma virus (HPV) infection was positively correlated with VAIN grade (P=0.028).Conclusions The VAIN grade is positively correlated with high-risk HPV infection.Afterloading intracavitary radiotherapy is an efficacious therapeutic approach for VAIN Ⅲ patients,which yields slight adverse events and high cure rate.