ABSTRACT
Objective: Cardiovascular disease [CVD] is the main cause of morbidity and premature mortality in end stage renal failure patients [ESRD] receiving dialysis. The aim of our study was to evaluate the impact of various risk factors in this group of high CVD risk patients in local population
Methods: We carried out a cross-sectional retrospective study in a single hospital. A total of 136 ESRF patients, consisted of 43 haemodialysis [HD] and 93 continuous ambulatory peritoneal dialysis [CAPD] patients, were recruited and followed up for 36 months duration. Midweek clinical and laboratory data were collected. The occurrence of existing and new CVD events was recorded
Results: Multiple Logistic Regression showed pre-existing cardiovascular event [odds ratio, 4.124, 95% confidence interval [CI], 0.990 to 17.187], elevated total cholesterol level [odds ratio, 0.550, 95% CI, 0.315 to 0.963], elevated serum phosphate level [odds ratio, 5.862, 95% CI, 1.041 to 33.024] and elevated random blood glucose level [odds ratio, 1.193, 95% CI, 1.012 to 1.406] were significantly associated with occurrence of CVD events
Conclusions: History of cardiovascular event before the initiation of dialysis, elevated level of serum phosphate and random blood glucose levels are the risk factors of CVD whereas paradoxically a high total cholesterol level has CVD protective effect towards the ESRF patients