Expression of TNF alpha Receptor p75in Skin and Sera of Patients with Psoriasis Vulgaris / 中华皮肤科杂志

Objective To study the role of tumor necrosis factor(TNF)?receptor75000(p75)in psoriasis vulgaris.Methods Expression of p75was detected by immunohistochemistry and enzyme-linked immunosorbent assay(ELISA)in skin and sera of patients with psoriasis vulgaris.Results Expression of p75was not found in skin of normal controls.p75expression was noted in epidermis of lesional and non-le-sional psoriatic skin,and in dermal infiltrating mononuclear cells(MNCs)of psoriatic skin.The staining in-tensity of p75on epidermal keratinocytes(EKCs)was significantly correlated(r' s =0.732,P