ABSTRACT
Objective To investigate the clinical effect of shuxuetong injection and its effects on oxidative stress in patients with type 2 diabetic nephropathy (DN).Methods One hundred and twenty cases with type 2 DN meeting the inclusion criteria were divided into two groups equally according to therapeutic scheme.Besides conventional treatments patients in the control group were treated with acarbose,while patients in the observation group were treated with shuxuetong injection and acarbose.The curative efficacy,renal function,superoxide dismutase (SOD),malonaldehyde (MDA) and advanced oxidation protein products (AOPPs) were recorded or detected.Results Therapeutic efficiency ratio (TER) in observation group was 93.3％,significantly higher than that in control group (80.0％;x2 =4.62,P =0.03).The levels of blood urea nitrogen (BUN),serum creatinine (Scr),urine total protein in observation group were (7.9 ± 2.3) mmol/L,(110.7±19.9) μumol/L and (2.2±0.5) g/24,lower than those in control group and the differences were significant ((11.5±2.7) mmol/L,(163.4±20.8) μmol/L and (2.9±0.5) g/24 h;t =7.86,14.48,7.67;P =＞0.000).Regarding of oxidative stress indices,MDA,AOPPs and SOD levels in observation were (3.5±0.4) μmol/L,(50.7±4.8) mmol/L and (56.7±3.8) kU/L,significant different from those in control group((6.7±0.3)μmol/L,(89.5 ± 5.6) mmo]/L and (35.4 ± 4.0) kU/L;t =49.57,40.75,29.90;P =0.00).During the treatment,there was no severe case with adverse reactions and the incidence of adverse reactions in the two groups (10.0％ vs 11.7％;x2 =0.09,P =0.77).Conclusion The method scheme of shuxuetong injection and acarbose on type 2 DN is effective with increasing the therapeutic efficiency ratio,improving renal function and alleviating oxidative stress with minor adverse reactions.