ABSTRACT
Selenium levels and the activity of Selenoenzyme glutathione peroxidase were measure in whole blood in order to assess the selenium status. Delayed type of hypersensitivity (DTH) reaction was suppressed significantly in selenium deficient rats indicating the decrease in cellular immunity. The B cell function was impaired in selenium deficient rats as evident from decrease in the number of plaque forming cells and antibody titre. Selenium supplementation for 30 days recovered the DTH response and B cell function to a marked extent.
Subject(s)
Animals , Antibody-Producing Cells/immunology , Deficiency Diseases/immunology , Hypersensitivity, Delayed , Immunity, Cellular , Rats , Selenium/administration & dosageABSTRACT
Feeding of selenium deficient diet to albino rats for 75 days resulted in increased levels of plasma and adrenal glucocorticoids and atrophy of spleen and thymus. Supplementing the diet with selenium for 30 days resulted in recovery of atrophy of spleen and thymus; plasma and adrenal glucocorticoid levels were also restored back to the normal.
Subject(s)
Animals , Atrophy , Dietary Supplements , Female , Rats , Rats, Wistar , Selenium/deficiency , Spleen/pathology , Thymus Gland/pathologyABSTRACT
In order to study the association between gastrin and H. pylori infection the density of antral G cells was evaluated by transcriptional expression of gastrin mRNA using a sensitive cold probe labelled with digoxigenin. the study group included 22 patients with symptomatic H. pylori positive gastritis and/or duodenal ulcer, 12 of whom were re-evaluated after eradication of H. pylori and 6 controls. The number of G cells per high power field in H.pylori positive patients (26.68 +/- 9.51) was significantly higher (P < 0.01) compared to controls (5.83 +/- 3.37). Among the 12 patients re-evaluated after H. pylori eradication, there was a significant decrease (P < 0.001) in the number of G cells (13.5 +/- 5.44) compared to pre-eradication value (26.25 +/- 8.0). The present study suggests that increased transcriptional expression of gastrin is directly related to H. pylori infection.
Subject(s)
Adolescent , Adult , Aged , Case-Control Studies , Female , Gastrins/genetics , Helicobacter Infections/metabolism , Helicobacter pylori , Humans , Male , Middle Aged , RNA, Messenger/biosynthesis , Transcription, GeneticABSTRACT
The role of selenium in the diet of rats has been examined with respect to the neutrophil functions. Feeding of Se-deficient diet for 75 days resulted in reduction in candidacidal activity, superoxide production, oxygen consumption, glucose utilisation and glutathione peroxidase activity. Supplementing the diet with Se for 30 days resulted in partial restoration of all the activities.
Subject(s)
Animals , Candida/immunology , Female , Neutrophils/immunology , Rats , Rats, Wistar , Selenium/deficiencyABSTRACT
Studies on the preventive role of trifluoperazine on cholesterol and adrenaline-induced experimental atherosclerosis in rabbits, revealed that trifluoperazine completely prevented the development of atherosclerotic lesions in both the aorta and coronary arteries of animals administered atherogenic diet and adrenaline (im) despite the fact that this drug had no significant effect on the elevated serum lipid profile induced by atherogenic diet. These findings confirm earlier observations of the authors that trifluoperazine has an inherent capacity to prevent atherogenesis.