1.
Indian Pediatr
;
2016 Oct; 53(10): 917-919
Article
in English
| IMSEAR
| ID: sea-179275
ABSTRACT
Background: Cerebrotendinous xanthomatosis is an inherited lipid storage disease manifesting with infantile onset diarrhea, cataracts, xanthomas and adult-onset neurological dysfunction with cerebellar signs and neuropathy. Case: 10-year-old boy presented with progressive ataxia, neuropathy and cataracts. Over 6 years, he developed dementia, kyphoscoliosis with worsening ataxia, and neuropathy. Outcome: Sterol analysis and CYP27A1 sequencing confirmed the diagnosis.Message: The condition should be considered in childhood onset cerebellar ataxia with cataracts, even in the absence of skin signs.