ABSTRACT
The study was carried out to determine the in vivo antioxidant and lipid peroxidation effect of methanolic extract of tuberous root of Ipomoea digitata (Linn). High fat diet rats showed significantly (P<0.001) reduced the levels of tissues enzymatic antioxidant and enhanced the level of non enzymatic antioxidant (Glutathione). The level of TBARS are elevated in HFD rats (group II) when compared with control group. High fat diet induces the oxidative stress in cell by producing reactive oxygen species. Administration of methanolic extract of Ipomoea digitata in high fat diet rats were showed increased the levels of antioxidant Enzymes such as Superoxide dismutase (SOD), Catalase (CAT), Glutathione peroxidase (GPx), Glutathione reductase (GR) and reduced the level of non enzymatic antioxidant Glutathione (GSH) when compared with HFD rats (Group II). The methanolic extract Ipomoea digitata in high fat diet rats were found lowered the concentration of TBARS when compared with HFD rats. Based on the results, we concluded that the methanolic extract of Ipomoea digitata is a significant source of natural antioxidant, which might be helpful in preventing the progress of various oxidative stresses.