ABSTRACT
Background: The study was done to investigate whether the raised levels of C-reactive protein (CRP), differential count and random blood glucose, besides echocardiogram, enhances the assessment process of acute coronary syndrome (ACS).Methods: This prospective study was done on 100 patients with typical chest pain attending to the department of medicine at K.A.P.V Medical College and Hospital, Trichy during the period from 2015 to 2017. The serum was assayed on admission for CRP, differential count and random blood glucose. Correlation of these parameters with incidence of ACS was calculated.Results: Male preponderance was seen in the study. Out of 100 patients, majority of about 60% of ACS patients had raised JVP. Elevated level of CRP was seen in 73% patients, 70% had elevated level of ejection fraction percentage. 71% had elevated level of WBC and 58% had elevated level of RBS. Statistically significant correlation was observed with the level of CRP (p=0.044), differential WBC count (p=0.037) and random blood glucose levels (p=0.001).Conclusions: Our study indicates that elevated CRP levels, increased random blood sugars and leucocytosis in ACS patient are positively correlated with decreased ejection fraction. Hence, measuring the levels of these parameters will helps in identifying incidence of acute coronary syndrome without echocardiogram.
ABSTRACT
Background: Pancytopenia is a serious and life threatening illness presented with multiple etiologies. The current study was done with the objective to evaluate the clinic-pathological factors responsible for incidence of pancytopenia in patients with vitamin B12 deficiency and their response to the therapy with vitamin B12.Methods: It was an observational study carried out at Department of Medicine, Mahatma Gandhi Memorial Government Hospital, Trichy, Tamilnadu during the period between December 2016 to December 2017. A total 50 patients with pancytopenia were clinically evaluated along with hematological parameters and bone marrow aspiration.Results: A total of 50 patients were included in the study. The mean age of the patients was 32.84 years with a male to female ratio of 1.5:1. All patients had history of fatigability. Commonest physical presentation was pallor (100%). Megaloblastic anaemia was the predominant blood picture in 58% patients. The common bone marrow finding was hyper cellular marrow with megaloblastic picture. Management with cyanocobalamin preparations and folate supplementations, significantly improved the reticulocyte count percentage in patients with pancytopenia (p=0.01)Conclusion: The study concluded that the most common cause of pancytopenia was megaloblastic anaemia. Detailed haematological investigations along with bone marrow aspiration in patients with cytopenia provided a clear understanding of disease process to identify the etiologies of pancytopenia.
ABSTRACT
Background: A stroke occurs when a blood vessel that carries oxygen and nutrients to the brain is either blocked by a clot or bursts (or ruptures). Computed tomography (CT) and magnetic resonance imaging (MRI) was done to determine the type of stroke. Diabetes mellitus is a well-recognized risk factor for ischemic stroke. The study was undertaken to assess the clinical characteristics, outcome pattern and to compare the pattern of stroke in diabetics and non-diabetics.Methods: An observational cross-sectional prospective study wherein a hundred stroke patients being admitted to MGMGH, Trichy were sampled and the clinical profile along with outcome is compared in diabetic and non- diabetic populations and the statistical significance of the same.Results: The proportion of patients with poor outcome following stroke was significantly higher in diabetics compared with non-diabetic patients being chi square value was 37.6514 and p value was found to be significantly less than 0.0001.Conclusions: The study resulted the large hemorrhages are twice as much common in the diabetic population compared to the non-diabetic population , the incidence increases with the chronicity of diabetes and the outcome is superior in the non-diabetics compared to the diabetics admitted in Mahatma Gandhi Memorial Government Hospital, Tiruchirappalli, Tamil Nadu, India.