ABSTRACT
Background: The prevalence of type 2 diabetes mellitus(T2DM) is growing worldwide, and these patients may beasymptomatic and present with complications at the time ofdiagnosis. Diabetic neuropathy is the most commoncomplication affecting the patients who may present with distalpolyneuropathy at the time of diagnosis and also poorglycaemic control. The Diabetic peripheral polyneuropathyaffects approximately 1 in every 10 newly diagnosed patients,whereas two third of patients with diabetes mellitus haveclinical or subclinical neuropathy.Objective: This study is designed to find prevalence of diabeticperipheral neuropathy in Newly Diagnosed Patients of T2DM ina tertiary care hospital.Materials and Methods: This observational study was carriedout in patients diagnosed with T2DM as per ADA criteria. Athorough clinical examination; Nerve conduction velocitytesting; evaluation of plasma glucose and glycosylatedhemoglobin and assessment of neuropathy by using theDiabetic neuropathy index and diabetic neuropathy score wasperformed on all patients.Results: 18% of patients had signs of peripheral neuropathyas shown by NCV testing at the time of diagnosis. Thesepatients had elevated levels of glycosylated hemoglobin,fasting plasma glucose and 2-hour plasma glucose and lowerscores of DNI and DNS which were statistically significant. Themost common type of neuropathy seen in these patients wassensorimotor involvement with demyelinating type ofneuropathy with more involvement of lower limbs. The NCVstudies showed reduced distal latency and prolongedamplitude as well as conduction velocity in patients withdiabetic neuropathy.Conclusion: Our study showed that approximately 1 in 5newly diagnosed patients with type 2 diabetes mellitus are atrisk of developing diabetic peripheral neuropathy.
ABSTRACT
Background: Garlic, latin name Allium Sativum, belongs to the onion family Alliaceae, have been widely recognized as agents for prevention and treatment of cardiovascular and other metabolic diseases like atherosclerosis, hyperlipidemia, thrombosis, hypertension and diabetes. Methods: This prospective study conducted on male smokers (n=40) in the department of physiology of Teerthanker Mahaveer Medical College & Research Centre. Selected smokers were further evaluated before and after giving raw fresh garlic weighing about 5-6gm daily for a month. Sample 1:- Before taking garlic parameters. Sample 2:- After taking garlic parameters. After one month all the parameters were analyzed and compared with the baseline parameters. Results: Garlic has a significant hypotensive effect by lowering DBP, SBP also lowered but it was not statistically significant. Also hypolipidemic effects of garlic were found to be statically significant in cases of triglyceride, HDL & LDL, but changes in cases of cholesterol and VLDL are not statically significant. Conclusions: Garlic being hypotensive and hypolipidemic in nature as shown in our study, therefore it can be concluded that garlic is beneficial for human beings. Its main beneficial effect for decreasing the lipid levels as well as the blood pressure in smokers.